Update on first-line treatment of advanced ovarian carcinoma
Z Kemp,1 JA Ledermann1,21Department of Oncology, University College London Hospitals, 2University College London Cancer Institute, University College London, London, United KingdomAbstract: Despite the high response rate to first-line treatment of advanced ovarian cancer, the vast majority of patien...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-01-01
|
| Series: | International Journal of Women's Health |
| Online Access: | http://www.dovepress.com/update-on-first-line-treatment-of-advanced-ovarian-carcinoma-a12066 |
| _version_ | 1819294677397929984 |
|---|---|
| author | Kemp Z Ledermann JA |
| author_facet | Kemp Z Ledermann JA |
| author_sort | Kemp Z |
| collection | DOAJ |
| description | Z Kemp,1 JA Ledermann1,21Department of Oncology, University College London Hospitals, 2University College London Cancer Institute, University College London, London, United KingdomAbstract: Despite the high response rate to first-line treatment of advanced ovarian cancer, the vast majority of patients relapse. Maximal debulking surgery and chemotherapy with a platinum doublet have remained the standard of care for many years and new approaches are imperative. Recent clinical trials have given grounds for hope. Neoadjuvant chemotherapy, intraperitoneal delivery, and dose-dense strategies have all shown promising results, as has the targeting of angiogenesis. A greater understanding of the molecular landscape of ovarian cancer is helping to identify new treatment options. In this review, we will highlight the key trials and recent progress in these areas.Keywords: ovarian cancer, first-line therapy, neoadjuvant, intraperitoneal, dose-dense, angiogenesis |
| first_indexed | 2024-12-24T04:30:07Z |
| format | Article |
| id | doaj.art-d0c953adc1a64d95aecdd5e7128700d2 |
| institution | Directory Open Access Journal |
| issn | 1179-1411 |
| language | English |
| last_indexed | 2024-12-24T04:30:07Z |
| publishDate | 2013-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Women's Health |
| spelling | doaj.art-d0c953adc1a64d95aecdd5e7128700d22022-12-21T17:15:27ZengDove Medical PressInternational Journal of Women's Health1179-14112013-01-012013default4551Update on first-line treatment of advanced ovarian carcinomaKemp ZLedermann JAZ Kemp,1 JA Ledermann1,21Department of Oncology, University College London Hospitals, 2University College London Cancer Institute, University College London, London, United KingdomAbstract: Despite the high response rate to first-line treatment of advanced ovarian cancer, the vast majority of patients relapse. Maximal debulking surgery and chemotherapy with a platinum doublet have remained the standard of care for many years and new approaches are imperative. Recent clinical trials have given grounds for hope. Neoadjuvant chemotherapy, intraperitoneal delivery, and dose-dense strategies have all shown promising results, as has the targeting of angiogenesis. A greater understanding of the molecular landscape of ovarian cancer is helping to identify new treatment options. In this review, we will highlight the key trials and recent progress in these areas.Keywords: ovarian cancer, first-line therapy, neoadjuvant, intraperitoneal, dose-dense, angiogenesishttp://www.dovepress.com/update-on-first-line-treatment-of-advanced-ovarian-carcinoma-a12066 |
| spellingShingle | Kemp Z Ledermann JA Update on first-line treatment of advanced ovarian carcinoma International Journal of Women's Health |
| title | Update on first-line treatment of advanced ovarian carcinoma |
| title_full | Update on first-line treatment of advanced ovarian carcinoma |
| title_fullStr | Update on first-line treatment of advanced ovarian carcinoma |
| title_full_unstemmed | Update on first-line treatment of advanced ovarian carcinoma |
| title_short | Update on first-line treatment of advanced ovarian carcinoma |
| title_sort | update on first line treatment of advanced ovarian carcinoma |
| url | http://www.dovepress.com/update-on-first-line-treatment-of-advanced-ovarian-carcinoma-a12066 |
| work_keys_str_mv | AT kempz updateonfirstlinetreatmentofadvancedovariancarcinoma AT ledermannja updateonfirstlinetreatmentofadvancedovariancarcinoma |