Genome Replication Is Associated With Release of Immunogenic DNA Waste

Genome Replication Is Associated With Release of Immunogenic DNA Waste

Innate DNA sensors detect foreign and endogenous DNA to induce responses to infection and cellular stress or damage. Inappropriate activation by self-DNA triggers severe autoinflammatory conditions, including Aicardi-Goutières syndrome (AGS) that can be caused by defects of the cytosolic DNase 3’rep...

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Bibliographic Details
Main Authors: Nadja Schubert, Tina Schumann, Elena Daum, Karolin Flade, Yan Ge, Lara Hagedorn, Winfried Edelmann, Luise Müller, Marc Schmitz, Gunnar Kuut, Veit Hornung, Rayk Behrendt, Axel Roers
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
Trex1
type I interferon
Exo1
replication
cytosolic DNA
interferonopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.880413/full

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