Aging and Cancer: The Waning of Community Bonds
Cancer often arises in the context of an altered tissue landscape. We argue that a major contribution of aging towards increasing the risk of neoplastic disease is conveyed through effects on the microenvironment. It is now firmly established that aged tissues are prone to develop clones of altered...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/9/2269 |
| _version_ | 1797519929378865152 |
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| author | Ezio Laconi Samuele Cheri Maura Fanti Fabio Marongiu |
| author_facet | Ezio Laconi Samuele Cheri Maura Fanti Fabio Marongiu |
| author_sort | Ezio Laconi |
| collection | DOAJ |
| description | Cancer often arises in the context of an altered tissue landscape. We argue that a major contribution of aging towards increasing the risk of neoplastic disease is conveyed through effects on the microenvironment. It is now firmly established that aged tissues are prone to develop clones of altered cells, most of which are compatible with a normal histological appearance. Such increased clonogenic potential results in part from a generalized decrease in proliferative fitness, favoring the emergence of more competitive variant clones. However, specific cellular genotypes can emerge with reduced cooperative and integrative capacity, leading to disruption of tissue architecture and paving the way towards progression to overt neoplastic phenotypes. |
| first_indexed | 2024-03-10T07:49:45Z |
| format | Article |
| id | doaj.art-d0cb38c375b54a6ba6103a750a97b30b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:49:45Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d0cb38c375b54a6ba6103a750a97b30b2023-11-22T12:23:28ZengMDPI AGCells2073-44092021-08-01109226910.3390/cells10092269Aging and Cancer: The Waning of Community BondsEzio Laconi0Samuele Cheri1Maura Fanti2Fabio Marongiu3Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, 09124 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, 09124 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, 09124 Cagliari, ItalyCancer often arises in the context of an altered tissue landscape. We argue that a major contribution of aging towards increasing the risk of neoplastic disease is conveyed through effects on the microenvironment. It is now firmly established that aged tissues are prone to develop clones of altered cells, most of which are compatible with a normal histological appearance. Such increased clonogenic potential results in part from a generalized decrease in proliferative fitness, favoring the emergence of more competitive variant clones. However, specific cellular genotypes can emerge with reduced cooperative and integrative capacity, leading to disruption of tissue architecture and paving the way towards progression to overt neoplastic phenotypes.https://www.mdpi.com/2073-4409/10/9/2269agingcancermicroenvironmenttissue ecologyclonal growth |
| spellingShingle | Ezio Laconi Samuele Cheri Maura Fanti Fabio Marongiu Aging and Cancer: The Waning of Community Bonds Cells aging cancer microenvironment tissue ecology clonal growth |
| title | Aging and Cancer: The Waning of Community Bonds |
| title_full | Aging and Cancer: The Waning of Community Bonds |
| title_fullStr | Aging and Cancer: The Waning of Community Bonds |
| title_full_unstemmed | Aging and Cancer: The Waning of Community Bonds |
| title_short | Aging and Cancer: The Waning of Community Bonds |
| title_sort | aging and cancer the waning of community bonds |
| topic | aging cancer microenvironment tissue ecology clonal growth |
| url | https://www.mdpi.com/2073-4409/10/9/2269 |
| work_keys_str_mv | AT eziolaconi agingandcancerthewaningofcommunitybonds AT samuelecheri agingandcancerthewaningofcommunitybonds AT maurafanti agingandcancerthewaningofcommunitybonds AT fabiomarongiu agingandcancerthewaningofcommunitybonds |