Channel Expansion in the Ligand-Binding Domain of the Glucocorticoid Receptor Contributes to the Activity of Highly Potent Glucocorticoid Analogues

Channel Expansion in the Ligand-Binding Domain of the Glucocorticoid Receptor Contributes to the Activity of Highly Potent Glucocorticoid Analogues

Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) and are commonly used as anti-inflammatory and immunosuppressant medications. Chronic GC use has been linked with unwanted complications such as steroid-induced diabetes mellitus (SIDM), although the mechanisms for these effects are...

Full description

Bibliographic Details
Main Authors: Wesley B. Seaton, Susan J. Burke, Alexander R. Fisch, William A. Schilletter, Mary Grace A. Beck, Gabrielle A. Cassagne, Innocence Harvey, Molly S. Fontenot, J. Jason Collier, Shawn R. Campagna
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
glucocorticoid
anti-inflammatory
transcription regulation
mercaptobenzothiazole
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/29/7/1546

Internet

https://www.mdpi.com/1420-3049/29/7/1546

Similar Items