Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes
In the present clinical study, the effect of oligofructose-enriched inulin was studied on bone metabolism in girls from 9 to 12 years old, with low habitual calcium intakes, who attended public schools. Two calcium-enriched formulations, supplemented with oligofructose-enriched inulin (test drink) o...
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2010-02-01
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| Series: | Brazilian Archives of Biology and Technology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000100024 |
| _version_ | 1811279934240325632 |
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| author | Maria Cristina Corrêa de Souza Franco Maria Lajolo Ligia de Araujo Martini Nelton Bespalez Correa Milana Cara Dan Elizabete Wenzel de Menezes |
| author_facet | Maria Cristina Corrêa de Souza Franco Maria Lajolo Ligia de Araujo Martini Nelton Bespalez Correa Milana Cara Dan Elizabete Wenzel de Menezes |
| author_sort | Maria Cristina Corrêa de Souza |
| collection | DOAJ |
| description | In the present clinical study, the effect of oligofructose-enriched inulin was studied on bone metabolism in girls from 9 to 12 years old, with low habitual calcium intakes, who attended public schools. Two calcium-enriched formulations, supplemented with oligofructose-enriched inulin (test drink) or without (standard drink) were made. Sixty pre-pubertal girls were randomized into a double-blind and crossover design, divided into three groups and received one daily portion of either the standard drink (group 1) or test drink (group 2) during 11 weeks, followed by a three-week washout period. Group control did not receive any supplementation. Biochemical evaluations of serum calcium, intact parathyroid hormone - iPTH - and bone alkaline phosphatase - BAP - were performed at baseline and after 4, 8 and 11 weeks of each intervention period. In group 1, a significant increase in serum calcium and BAP and a reduction of iPTH were observed after consumption of the test drink.<br>No presente ensaio clínico, o efeito de oligofrutose enriquecida com inulina foi estudado no metabolismo ósseo de meninas de 9 a 12 anos com baixa ingestão habitual de cálcio, matriculadas em escolas públicas. Duas formulações foram suplementadas ou não (bebida padrão) com oligofrutose enriquecida com inulina (bebida teste). Sessenta meninas pré-púberes foram aleatorizadas em estudo duplo cego crossover e divididas em três grupos e receberam uma porção diária da bebida padrão (grupo 1) ou teste (grupo 2) durante 11 semanas, seguidos por um período de intervalo de três semanas. O grupo controle não recebeu nenhuma suplementação. As avaliações bioquímicas de cálcio sérico, paratormônio intacto - PTHi e fosfatase alcalina fração óssea - FAO foram executadas ao início e após 4, 8 e 11 semanas de cada período de intervenção. No grupo 1, um aumento significante no cálcio sérico e FAO e uma redução no PTHi foram observadas após o consumo da bebida teste. |
| first_indexed | 2024-04-13T01:04:41Z |
| format | Article |
| id | doaj.art-d0cbc69b45534c668bf96f14d63e8e36 |
| institution | Directory Open Access Journal |
| issn | 1516-8913 1678-4324 |
| language | English |
| last_indexed | 2024-04-13T01:04:41Z |
| publishDate | 2010-02-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-d0cbc69b45534c668bf96f14d63e8e362022-12-22T03:09:24ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1516-89131678-43242010-02-0153119320110.1590/S1516-89132010000100024Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakesMaria Cristina Corrêa de SouzaFranco Maria LajoloLigia de Araujo MartiniNelton Bespalez CorreaMilana Cara DanElizabete Wenzel de MenezesIn the present clinical study, the effect of oligofructose-enriched inulin was studied on bone metabolism in girls from 9 to 12 years old, with low habitual calcium intakes, who attended public schools. Two calcium-enriched formulations, supplemented with oligofructose-enriched inulin (test drink) or without (standard drink) were made. Sixty pre-pubertal girls were randomized into a double-blind and crossover design, divided into three groups and received one daily portion of either the standard drink (group 1) or test drink (group 2) during 11 weeks, followed by a three-week washout period. Group control did not receive any supplementation. Biochemical evaluations of serum calcium, intact parathyroid hormone - iPTH - and bone alkaline phosphatase - BAP - were performed at baseline and after 4, 8 and 11 weeks of each intervention period. In group 1, a significant increase in serum calcium and BAP and a reduction of iPTH were observed after consumption of the test drink.<br>No presente ensaio clínico, o efeito de oligofrutose enriquecida com inulina foi estudado no metabolismo ósseo de meninas de 9 a 12 anos com baixa ingestão habitual de cálcio, matriculadas em escolas públicas. Duas formulações foram suplementadas ou não (bebida padrão) com oligofrutose enriquecida com inulina (bebida teste). Sessenta meninas pré-púberes foram aleatorizadas em estudo duplo cego crossover e divididas em três grupos e receberam uma porção diária da bebida padrão (grupo 1) ou teste (grupo 2) durante 11 semanas, seguidos por um período de intervalo de três semanas. O grupo controle não recebeu nenhuma suplementação. As avaliações bioquímicas de cálcio sérico, paratormônio intacto - PTHi e fosfatase alcalina fração óssea - FAO foram executadas ao início e após 4, 8 e 11 semanas de cada período de intervenção. No grupo 1, um aumento significante no cálcio sérico e FAO e uma redução no PTHi foram observadas após o consumo da bebida teste.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000100024Oligofructose-enriched inulincalcium intakesbone markersprepubertal girlsprebioticsbone and mineral metabolism |
| spellingShingle | Maria Cristina Corrêa de Souza Franco Maria Lajolo Ligia de Araujo Martini Nelton Bespalez Correa Milana Cara Dan Elizabete Wenzel de Menezes Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes Brazilian Archives of Biology and Technology Oligofructose-enriched inulin calcium intakes bone markers prepubertal girls prebiotics bone and mineral metabolism |
| title | Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes |
| title_full | Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes |
| title_fullStr | Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes |
| title_full_unstemmed | Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes |
| title_short | Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes |
| title_sort | effect of oligofructose enriched inulin on bone metabolism in girls with low calcium intakes |
| topic | Oligofructose-enriched inulin calcium intakes bone markers prepubertal girls prebiotics bone and mineral metabolism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000100024 |
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