THE FACTORS OF SALMONELLA VIRULENCY AND PATHOGENESIS OF THE SALMONELLA INFECTION
Salmonella pathogenesis relies upon the delivery of over thirty specialized effector proteins into the host cell via two distinct type III secretion systems. These effectors act in concert to subvert the host cell cytoskeleton, signal transduction pathways, membrane trafficking and proinflammatory r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Odessa I. I. Mechnikov National University
2010-12-01
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| Series: | Mìkrobìologìâ ì Bìotehnologìâ |
| Subjects: | |
| Online Access: | http://mbt.onu.edu.ua/article/view/97142 |
| Summary: | Salmonella pathogenesis relies upon the delivery of over thirty specialized effector proteins into the host cell via two distinct type III secretion systems. These effectors act in concert to subvert the host cell cytoskeleton, signal transduction pathways, membrane trafficking and proinflammatory responses. This allows Salmonella to invade non-phagocytic epithelial cells, establish and maintain an intracellular replicative niche and, in some cases, disseminate to cause systemic diseases. This review focuses on the action of the effectors on their host cell targets during each stage of Salmonella infection. |
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| ISSN: | 2076-0558 2307-4663 |