| Summary: | Honey bees (<i>Apis mellifera</i>) are one of the most important pollinating species of flowering plants. Recently, populations of honey bees have been declining due to a combination of factors, including the widespread use of agricultural pesticides. Laboratory studies were conducted to determine the acute oral toxicity of different formulated pesticides to honey bee adults. In particular, we assessed the acute oral toxicity of two neonicotinoids (acetamiprid, Assail 30SG and thiamethoxam, Actara 25WDG) and two other systemic insecticide products (sulfoxaflor, Closer 2SC and flupyradifurone, Sivanto 200SL), all of which are generally used in pest management programs in commercial apple orchards in the Eastern United States. Honey bees were fed a range of doses of each pesticide in order to create a response curve, and LC<sub>50</sub>, LC<sub>90</sub>, and LD<sub>50</sub> values were determined. The pesticide formulation containing flupyradifurone as the active ingredient was found to be the least toxic to honey bees followed by the formulations containing sulfoxaflor and acetamiprid. The toxicity values obtained in this study differ from other studies testing only technical active ingredient compounds, suggesting the need to evaluate formulated products while conducting ecotoxicological risk assessment.
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