The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an immune response largely mediated by natural killer (NK) cells that can lyse target cells and combat tumors and viral infections. However, the role of ADCC in response to primary HIV infection is poorly understood. In the present study, we ex...
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02322/full |
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| author | Xi Chen Xi Chen Xi Chen Xi Chen Meilin Lin Meilin Lin Meilin Lin Meilin Lin Meilin Lin Shi Qian Shi Qian Shi Qian Shi Qian Zining Zhang Zining Zhang Zining Zhang Zining Zhang Yajing Fu Yajing Fu Yajing Fu Yajing Fu Junjie Xu Junjie Xu Junjie Xu Junjie Xu Xiaoxu Han Xiaoxu Han Xiaoxu Han Xiaoxu Han Haibo Ding Haibo Ding Haibo Ding Haibo Ding Tao Dong Hong Shang Hong Shang Hong Shang Hong Shang Yongjun Jiang Yongjun Jiang Yongjun Jiang Yongjun Jiang |
| author_facet | Xi Chen Xi Chen Xi Chen Xi Chen Meilin Lin Meilin Lin Meilin Lin Meilin Lin Meilin Lin Shi Qian Shi Qian Shi Qian Shi Qian Zining Zhang Zining Zhang Zining Zhang Zining Zhang Yajing Fu Yajing Fu Yajing Fu Yajing Fu Junjie Xu Junjie Xu Junjie Xu Junjie Xu Xiaoxu Han Xiaoxu Han Xiaoxu Han Xiaoxu Han Haibo Ding Haibo Ding Haibo Ding Haibo Ding Tao Dong Hong Shang Hong Shang Hong Shang Hong Shang Yongjun Jiang Yongjun Jiang Yongjun Jiang Yongjun Jiang |
| author_sort | Xi Chen |
| collection | DOAJ |
| description | Antibody-dependent cell-mediated cytotoxicity (ADCC) is an immune response largely mediated by natural killer (NK) cells that can lyse target cells and combat tumors and viral infections. However, the role of ADCC in response to primary HIV infection is poorly understood. In the present study, we explored the ADCC response and evaluated its characteristics in 85 HIV-infected individuals, including 42 with primary infections. Our results showed that ADCC occurs during acute infection, and the earliest ADCC response to a single peptide was detected at 52 days. Primary HIV-infected individuals exhibiting ADCC responses had lower viral set points than those with no ADCC response, and functional analyses demonstrated that the ADCC response could significantly inhibit viral infection during primary HIV infection. HIV epitopes that provoked the ADCC response were determined and three relatively conserved epitopes (HNVWATYACVPTDPNPQE, TSVIKQACPKISFDPIPI, and VVSTQLLLNGSLAEEEII) from the surface of the three-dimensional structure of the HIV Env protein were identified. Overall, our data indicate that ADCC responses may be significant for the control of HIV from an early stage during infection. These findings merit further investigation and will facilitate improvements in vaccines or therapeutic interventions against HIV infection. |
| first_indexed | 2024-12-22T04:50:39Z |
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| language | English |
| last_indexed | 2024-12-22T04:50:39Z |
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| spelling | doaj.art-d0ce67b2bf2e46bb817b6e9bc3b608a42022-12-21T18:38:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-10-01910.3389/fimmu.2018.02322408781The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV InfectionXi Chen0Xi Chen1Xi Chen2Xi Chen3Meilin Lin4Meilin Lin5Meilin Lin6Meilin Lin7Meilin Lin8Shi Qian9Shi Qian10Shi Qian11Shi Qian12Zining Zhang13Zining Zhang14Zining Zhang15Zining Zhang16Yajing Fu17Yajing Fu18Yajing Fu19Yajing Fu20Junjie Xu21Junjie Xu22Junjie Xu23Junjie Xu24Xiaoxu Han25Xiaoxu Han26Xiaoxu Han27Xiaoxu Han28Haibo Ding29Haibo Ding30Haibo Ding31Haibo Ding32Tao Dong33Hong Shang34Hong Shang35Hong Shang36Hong Shang37Yongjun Jiang38Yongjun Jiang39Yongjun Jiang40Yongjun Jiang41Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaAffiliated Hospital of Hebei University, Baoding, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaMRC Human Immunology Unit, Radcliffe Department of Medicine, Oxford University, Oxford, United KingdomKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of AIDS Immunology, Chinese Academy of Medical Sciences, Shenyang, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, ChinaAntibody-dependent cell-mediated cytotoxicity (ADCC) is an immune response largely mediated by natural killer (NK) cells that can lyse target cells and combat tumors and viral infections. However, the role of ADCC in response to primary HIV infection is poorly understood. In the present study, we explored the ADCC response and evaluated its characteristics in 85 HIV-infected individuals, including 42 with primary infections. Our results showed that ADCC occurs during acute infection, and the earliest ADCC response to a single peptide was detected at 52 days. Primary HIV-infected individuals exhibiting ADCC responses had lower viral set points than those with no ADCC response, and functional analyses demonstrated that the ADCC response could significantly inhibit viral infection during primary HIV infection. HIV epitopes that provoked the ADCC response were determined and three relatively conserved epitopes (HNVWATYACVPTDPNPQE, TSVIKQACPKISFDPIPI, and VVSTQLLLNGSLAEEEII) from the surface of the three-dimensional structure of the HIV Env protein were identified. Overall, our data indicate that ADCC responses may be significant for the control of HIV from an early stage during infection. These findings merit further investigation and will facilitate improvements in vaccines or therapeutic interventions against HIV infection.https://www.frontiersin.org/article/10.3389/fimmu.2018.02322/fullhuman immunodeficiency virusnatural killer cellsprimary HIV infectionantibody-dependent cell-mediated cytotoxicityepitopes |
| spellingShingle | Xi Chen Xi Chen Xi Chen Xi Chen Meilin Lin Meilin Lin Meilin Lin Meilin Lin Meilin Lin Shi Qian Shi Qian Shi Qian Shi Qian Zining Zhang Zining Zhang Zining Zhang Zining Zhang Yajing Fu Yajing Fu Yajing Fu Yajing Fu Junjie Xu Junjie Xu Junjie Xu Junjie Xu Xiaoxu Han Xiaoxu Han Xiaoxu Han Xiaoxu Han Haibo Ding Haibo Ding Haibo Ding Haibo Ding Tao Dong Hong Shang Hong Shang Hong Shang Hong Shang Yongjun Jiang Yongjun Jiang Yongjun Jiang Yongjun Jiang The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection Frontiers in Immunology human immunodeficiency virus natural killer cells primary HIV infection antibody-dependent cell-mediated cytotoxicity epitopes |
| title | The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection |
| title_full | The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection |
| title_fullStr | The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection |
| title_full_unstemmed | The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection |
| title_short | The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection |
| title_sort | early antibody dependent cell mediated cytotoxicity response is associated with lower viral set point in individuals with primary hiv infection |
| topic | human immunodeficiency virus natural killer cells primary HIV infection antibody-dependent cell-mediated cytotoxicity epitopes |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02322/full |
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