Computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes
Transcranial Magnetic Stimulation is an emerging non-invasive treatment for depression, Parkinson’s disease, and a variety of other neurological disorders. Many Parkinson’s patients receive the treatment known as Deep Brain Stimulation, but often require additional therapy for speech and swallowing...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2017-05-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/1.4974062 |
| _version_ | 1819263526969016320 |
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| author | F. Syeda K. Holloway A. A. El-Gendy R. L. Hadimani |
| author_facet | F. Syeda K. Holloway A. A. El-Gendy R. L. Hadimani |
| author_sort | F. Syeda |
| collection | DOAJ |
| description | Transcranial Magnetic Stimulation is an emerging non-invasive treatment for depression, Parkinson’s disease, and a variety of other neurological disorders. Many Parkinson’s patients receive the treatment known as Deep Brain Stimulation, but often require additional therapy for speech and swallowing impairment. Transcranial Magnetic Stimulation has been explored as a possible treatment by stimulating the mouth motor area of the brain. We have calculated induced electric field, magnetic field, and temperature distributions in the brain using finite element analysis and anatomically realistic heterogeneous head models fitted with Deep Brain Stimulation leads. A Figure of 8 coil, current of 5000 A, and frequency of 2.5 kHz are used as simulation parameters. Results suggest that Deep Brain Stimulation leads cause surrounding tissues to experience slightly increased E-field (ΔEmax=30 V/m), but not exceeding the nominal values induced in brain tissue by Transcranial Magnetic Stimulation without leads (215 V/m). The maximum temperature in the brain tissues surrounding leads did not change significantly from the normal human body temperature of 37 °C. Therefore, we ascertain that Transcranial Magnetic Stimulation in the mouth motor area may stimulate brain tissue surrounding Deep Brain Stimulation leads, but will not cause tissue damage. |
| first_indexed | 2024-12-23T20:15:00Z |
| format | Article |
| id | doaj.art-d0cee59fd4b24ecea26d493428f094e9 |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-12-23T20:15:00Z |
| publishDate | 2017-05-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-d0cee59fd4b24ecea26d493428f094e92022-12-21T17:32:44ZengAIP Publishing LLCAIP Advances2158-32262017-05-0175056709056709-510.1063/1.4974062114791ADVComputational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probesF. Syeda0K. Holloway1A. A. El-Gendy2R. L. Hadimani3Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USADepartment of Neurosurgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23284, USADepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USADepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USATranscranial Magnetic Stimulation is an emerging non-invasive treatment for depression, Parkinson’s disease, and a variety of other neurological disorders. Many Parkinson’s patients receive the treatment known as Deep Brain Stimulation, but often require additional therapy for speech and swallowing impairment. Transcranial Magnetic Stimulation has been explored as a possible treatment by stimulating the mouth motor area of the brain. We have calculated induced electric field, magnetic field, and temperature distributions in the brain using finite element analysis and anatomically realistic heterogeneous head models fitted with Deep Brain Stimulation leads. A Figure of 8 coil, current of 5000 A, and frequency of 2.5 kHz are used as simulation parameters. Results suggest that Deep Brain Stimulation leads cause surrounding tissues to experience slightly increased E-field (ΔEmax=30 V/m), but not exceeding the nominal values induced in brain tissue by Transcranial Magnetic Stimulation without leads (215 V/m). The maximum temperature in the brain tissues surrounding leads did not change significantly from the normal human body temperature of 37 °C. Therefore, we ascertain that Transcranial Magnetic Stimulation in the mouth motor area may stimulate brain tissue surrounding Deep Brain Stimulation leads, but will not cause tissue damage.http://dx.doi.org/10.1063/1.4974062 |
| spellingShingle | F. Syeda K. Holloway A. A. El-Gendy R. L. Hadimani Computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes AIP Advances |
| title | Computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes |
| title_full | Computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes |
| title_fullStr | Computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes |
| title_full_unstemmed | Computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes |
| title_short | Computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes |
| title_sort | computational analysis of transcranial magnetic stimulation in the presence of deep brain stimulation probes |
| url | http://dx.doi.org/10.1063/1.4974062 |
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