Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma
Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequenc...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2016-03-01
|
| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/911 |
| _version_ | 1811223075395469312 |
|---|---|
| author | Megan L. Ludwig Andrew C. Birkeland Rebecca Hoesli Paul Swiecicki Matthew E. Spector J. Chad Brenner |
| author_facet | Megan L. Ludwig Andrew C. Birkeland Rebecca Hoesli Paul Swiecicki Matthew E. Spector J. Chad Brenner |
| author_sort | Megan L. Ludwig |
| collection | DOAJ |
| description | Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21<sup>st</sup> century. |
| first_indexed | 2024-04-12T08:26:45Z |
| format | Article |
| id | doaj.art-d0d00af2eded4ef68b10407d401db0e5 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 2095-3941 |
| language | English |
| last_indexed | 2024-04-12T08:26:45Z |
| publishDate | 2016-03-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-d0d00af2eded4ef68b10407d401db0e52022-12-22T03:40:22ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412016-03-011318710010.20892/j.issn.2095-3941.2016.00102016000010Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinomaMegan L. Ludwig0Andrew C. Birkeland1Rebecca Hoesli2Paul Swiecicki3Matthew E. Spector4J. Chad Brenner5Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Department of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21<sup>st</sup> century.http://www.cancerbiomed.org/index.php/cocr/article/view/911Head and neck cancerlaryngeal squamous cell carcinomageneticstargeted therapypersonalized medicine |
| spellingShingle | Megan L. Ludwig Andrew C. Birkeland Rebecca Hoesli Paul Swiecicki Matthew E. Spector J. Chad Brenner Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma Cancer Biology & Medicine Head and neck cancer laryngeal squamous cell carcinoma genetics targeted therapy personalized medicine |
| title | Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma |
| title_full | Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma |
| title_fullStr | Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma |
| title_full_unstemmed | Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma |
| title_short | Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma |
| title_sort | changing the paradigm the potential for targeted therapy in laryngeal squamous cell carcinoma |
| topic | Head and neck cancer laryngeal squamous cell carcinoma genetics targeted therapy personalized medicine |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/911 |
| work_keys_str_mv | AT meganlludwig changingtheparadigmthepotentialfortargetedtherapyinlaryngealsquamouscellcarcinoma AT andrewcbirkeland changingtheparadigmthepotentialfortargetedtherapyinlaryngealsquamouscellcarcinoma AT rebeccahoesli changingtheparadigmthepotentialfortargetedtherapyinlaryngealsquamouscellcarcinoma AT paulswiecicki changingtheparadigmthepotentialfortargetedtherapyinlaryngealsquamouscellcarcinoma AT matthewespector changingtheparadigmthepotentialfortargetedtherapyinlaryngealsquamouscellcarcinoma AT jchadbrenner changingtheparadigmthepotentialfortargetedtherapyinlaryngealsquamouscellcarcinoma |