Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study
Background: Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population. However, there is no standard treatment. Cryotherapy has been reported as an alternative therapy for years; nevertheless, there is no randomized controlled study to determine...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-04-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2016.1221498 |
| _version_ | 1797684030787813376 |
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| author | Kulwadee Laosakul Premjit Juntongjin |
| author_facet | Kulwadee Laosakul Premjit Juntongjin |
| author_sort | Kulwadee Laosakul |
| collection | DOAJ |
| description | Background: Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population. However, there is no standard treatment. Cryotherapy has been reported as an alternative therapy for years; nevertheless, there is no randomized controlled study to determine its efficacy. Objectives: To evaluate the efficacy and side effects of tip cryotherapy in IGH treatment. Material and methods: Total 101 lesions were included. Forty-three lesions were treated with cryotherapy and 58 lesions were assigned as control. A single session of tip cryotherapy was delivered and remained for 5 s. Colorimeter was used to measure lesional luminosity at baseline and then monthly until 4 months. Digital photographs were evaluated by two blinded dermatologists. In addition, patients’ assessments and side effects were assessed. Results: Mean luminosity scale gradually decreased from baseline. Also, the score of the treated lesions has been significantly lower than that of the control lesions since week 8 (p = .005). At the fourth month, dermatologists’ assessment revealed that 82.3% of the treated lesions comparing to only 2% of the control showed more than 75% improvement (p < .001). Burning sensation was the most common side effect. Conclusion: Tip cryotherapy appears to be an effective therapy with minimal adverse effect for IGH. |
| first_indexed | 2024-03-12T00:23:28Z |
| format | Article |
| id | doaj.art-d0d0dcf08165451180d7b03fbdd3b92c |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:23:28Z |
| publishDate | 2017-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-d0d0dcf08165451180d7b03fbdd3b92c2023-09-15T10:48:02ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532017-04-0128327127510.1080/09546634.2016.12214981221498Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded studyKulwadee Laosakul0Premjit Juntongjin1Thammasat UniversityThammasat UniversityBackground: Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population. However, there is no standard treatment. Cryotherapy has been reported as an alternative therapy for years; nevertheless, there is no randomized controlled study to determine its efficacy. Objectives: To evaluate the efficacy and side effects of tip cryotherapy in IGH treatment. Material and methods: Total 101 lesions were included. Forty-three lesions were treated with cryotherapy and 58 lesions were assigned as control. A single session of tip cryotherapy was delivered and remained for 5 s. Colorimeter was used to measure lesional luminosity at baseline and then monthly until 4 months. Digital photographs were evaluated by two blinded dermatologists. In addition, patients’ assessments and side effects were assessed. Results: Mean luminosity scale gradually decreased from baseline. Also, the score of the treated lesions has been significantly lower than that of the control lesions since week 8 (p = .005). At the fourth month, dermatologists’ assessment revealed that 82.3% of the treated lesions comparing to only 2% of the control showed more than 75% improvement (p < .001). Burning sensation was the most common side effect. Conclusion: Tip cryotherapy appears to be an effective therapy with minimal adverse effect for IGH.http://dx.doi.org/10.1080/09546634.2016.1221498idiopathic guttate hypomelanosistip cryotherapycryotherapyliquid nitrogencryosurgeryleukodermatherapeutic wounding |
| spellingShingle | Kulwadee Laosakul Premjit Juntongjin Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study Journal of Dermatological Treatment idiopathic guttate hypomelanosis tip cryotherapy cryotherapy liquid nitrogen cryosurgery leukoderma therapeutic wounding |
| title | Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study |
| title_full | Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study |
| title_fullStr | Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study |
| title_full_unstemmed | Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study |
| title_short | Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study |
| title_sort | efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis igh a randomized controlled evaluator blinded study |
| topic | idiopathic guttate hypomelanosis tip cryotherapy cryotherapy liquid nitrogen cryosurgery leukoderma therapeutic wounding |
| url | http://dx.doi.org/10.1080/09546634.2016.1221498 |
| work_keys_str_mv | AT kulwadeelaosakul efficacyoftipcryotherapyinthetreatmentofidiopathicguttatehypomelanosisigharandomizedcontrolledevaluatorblindedstudy AT premjitjuntongjin efficacyoftipcryotherapyinthetreatmentofidiopathicguttatehypomelanosisigharandomizedcontrolledevaluatorblindedstudy |