Allosteric regulation of autoinhibition and activation of c-Abl

Allosteric regulation of autoinhibition and activation of c-Abl

c-Abl, a non-receptor tyrosine kinase, regulates cell growth and survival in healthy cells and causes chronic myeloid leukemia (CML) when fused by Bcr. Its activity is blocked in the assembled inactive state, where the SH3 and SH2 domains dock into the kinase domain, reducing its conformational flex...

Full description

Bibliographic Details
Main Authors: Yonglan Liu, Mingzhen Zhang, Chung-Jung Tsai, Hyunbum Jang, Ruth Nussinov
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Allostery
Kinase
Chronic myeloid leukemia
Bcr-Abl
Allosteric drug
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003488

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022003488

Similar Items