Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy—effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker

Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy—effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker

Abstract Background Host factors such as angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease, serine-subtype-2 (TMPRSS2) are important factors for SARS-CoV-2 infection. Clinical and pre-clinical studies demonstrated that RAAS-blocking agents can be safely used during a SARS-CoV-2 i...

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Bibliographic Details
Main Authors: Yingquan Xiong, Denis Delic, Shufei Zeng, Xin Chen, Chang Chu, Ahmed A. Hasan, Bernhard K. Krämer, Thomas Klein, Lianghong Yin, Berthold Hocher
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Nephrology
Subjects:
SARS CoV-2 host factors
5/6 nephrectomy
High-salt diet
ARB
DPP4 inhibitor
SGLT2 blocker
Online Access:https://doi.org/10.1186/s12882-022-02747-1

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