Apolipoprotein D concentration in Parkinson’s disease patients
Abstract Background Parkinson’s disease (PD) is distinguished recently by an increase in inflammation and oxidative stress. Apolipoprotein D (Apo D) is a neuroprotective protein that was discovered to be increased in PD-affected brains. The aim of our study was to measure the ApoD serum level in ind...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-11-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00746-z |
| _version_ | 1797630408006828032 |
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| author | Hala A. Shaheen Sayed Sobhy Sherine El Mously Mohammed Mansour Abbas Eid Marwa Hanafy Abo Omirah Asmaa Abbas Mohammed Gomaa |
| author_facet | Hala A. Shaheen Sayed Sobhy Sherine El Mously Mohammed Mansour Abbas Eid Marwa Hanafy Abo Omirah Asmaa Abbas Mohammed Gomaa |
| author_sort | Hala A. Shaheen |
| collection | DOAJ |
| description | Abstract Background Parkinson’s disease (PD) is distinguished recently by an increase in inflammation and oxidative stress. Apolipoprotein D (Apo D) is a neuroprotective protein that was discovered to be increased in PD-affected brains. The aim of our study was to measure the ApoD serum level in individuals with PD and to correlate it with the clinical data of those individuals. Thirty individuals suffering from idiopathic PD were subjected to neurological examination, disease intensity by applying the Unified Parkinson’s Disease Rating Scale (UPDRS) and measurement of Apo D blood levels. Thirty age and sex matched controls were included for comparison of Apo D concentration. Results Apolipoprotein D levels were substantially greater in PD individuals than in controls. The correlation between Apo D serum level and PD severity determined by the UPDRS and its subscales was positive. Conclusion PD patients had increased blood level concentration of Apo D, which was associated positively with disease intensity. We suggest that Apo D serum level can be used as a predictor factor for PD severity. More studies are warranted to study how to target the Apo D in PD patients and thus helping to reduce the oxidative stress and inflammatory cascade involved in the pathogenesis of the disease. |
| first_indexed | 2024-03-11T11:06:56Z |
| format | Article |
| id | doaj.art-d0d4c84824e5443b9aaa856eb06b8b72 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-03-11T11:06:56Z |
| publishDate | 2023-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-d0d4c84824e5443b9aaa856eb06b8b722023-11-12T12:10:34ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292023-11-015911610.1186/s41983-023-00746-zApolipoprotein D concentration in Parkinson’s disease patientsHala A. Shaheen0Sayed Sobhy1Sherine El Mously2Mohammed Mansour Abbas Eid3Marwa Hanafy Abo Omirah4Asmaa Abbas5Mohammed Gomaa6Department of Neurology, Faculty of Medicine, Fayoum UniversityDepartment of Neurology, Faculty of Medicine, Fayoum UniversityDepartment of Neurology, Faculty of Medicine, Fayoum UniversityDepartment of Clinical Pathology, Faculty of Medicine, Fayoum UniversityDepartment of Neurology, Faculty of Medicine, Fayoum UniversityDepartment of Neurology, Faculty of Medicine, Fayoum UniversityDepartment of Neurology, Faculty of Medicine, Fayoum UniversityAbstract Background Parkinson’s disease (PD) is distinguished recently by an increase in inflammation and oxidative stress. Apolipoprotein D (Apo D) is a neuroprotective protein that was discovered to be increased in PD-affected brains. The aim of our study was to measure the ApoD serum level in individuals with PD and to correlate it with the clinical data of those individuals. Thirty individuals suffering from idiopathic PD were subjected to neurological examination, disease intensity by applying the Unified Parkinson’s Disease Rating Scale (UPDRS) and measurement of Apo D blood levels. Thirty age and sex matched controls were included for comparison of Apo D concentration. Results Apolipoprotein D levels were substantially greater in PD individuals than in controls. The correlation between Apo D serum level and PD severity determined by the UPDRS and its subscales was positive. Conclusion PD patients had increased blood level concentration of Apo D, which was associated positively with disease intensity. We suggest that Apo D serum level can be used as a predictor factor for PD severity. More studies are warranted to study how to target the Apo D in PD patients and thus helping to reduce the oxidative stress and inflammatory cascade involved in the pathogenesis of the disease.https://doi.org/10.1186/s41983-023-00746-zParkinson’s diseaseApolipoprotein DUnified Parkinson’s Disease Rating Scale |
| spellingShingle | Hala A. Shaheen Sayed Sobhy Sherine El Mously Mohammed Mansour Abbas Eid Marwa Hanafy Abo Omirah Asmaa Abbas Mohammed Gomaa Apolipoprotein D concentration in Parkinson’s disease patients The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Parkinson’s disease Apolipoprotein D Unified Parkinson’s Disease Rating Scale |
| title | Apolipoprotein D concentration in Parkinson’s disease patients |
| title_full | Apolipoprotein D concentration in Parkinson’s disease patients |
| title_fullStr | Apolipoprotein D concentration in Parkinson’s disease patients |
| title_full_unstemmed | Apolipoprotein D concentration in Parkinson’s disease patients |
| title_short | Apolipoprotein D concentration in Parkinson’s disease patients |
| title_sort | apolipoprotein d concentration in parkinson s disease patients |
| topic | Parkinson’s disease Apolipoprotein D Unified Parkinson’s Disease Rating Scale |
| url | https://doi.org/10.1186/s41983-023-00746-z |
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