An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal properties
A versatile and environmentally friendly method for the synthesis of various organophosphorus compounds have been developed under microware conditions. We have synthesized a series of the trifluoromethyl phosphonates via Phospha-Brook rearrangement between dialkylphosphite and 3-(trifluoroacetyl)cou...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610321000788 |
| _version_ | 1818622413300039680 |
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| author | Lulu Wu Xinxin Yuan Guoyu Yang Cuilian Xu Zhenliang Pan Lijun Shi Caixia Wang Liangxin Fan |
| author_facet | Lulu Wu Xinxin Yuan Guoyu Yang Cuilian Xu Zhenliang Pan Lijun Shi Caixia Wang Liangxin Fan |
| author_sort | Lulu Wu |
| collection | DOAJ |
| description | A versatile and environmentally friendly method for the synthesis of various organophosphorus compounds have been developed under microware conditions. We have synthesized a series of the trifluoromethyl phosphonates via Phospha-Brook rearrangement between dialkylphosphite and 3-(trifluoroacetyl)coumarins using KF/Al2O3 as a highly efficient solid catalyst under solventless conditions. Catalyst reuse, ease of separation of the pure product, and high yields are some of the unique features of this process. In addition, the mycelial growth rate method was used to examine the in vitro antifungal activities of the phosphates 4a-o against Phytophthora capsici, Fusarium oxysporum vasinfectum, Bipolaris maydis and Alternaria solani at 500 µg/mL. The results showed that compound 4n exhibited significant anti-Phytophthora capsici activity with inhibitory index of 86%. |
| first_indexed | 2024-12-16T18:24:46Z |
| format | Article |
| id | doaj.art-d0d548dcbc1c43ad871178ebb8395e6d |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-16T18:24:46Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-d0d548dcbc1c43ad871178ebb8395e6d2022-12-21T22:21:28ZengElsevierJournal of Saudi Chemical Society1319-61032021-07-01257101273An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal propertiesLulu Wu0Xinxin Yuan1Guoyu Yang2Cuilian Xu3Zhenliang Pan4Lijun Shi5Caixia Wang6Liangxin Fan7College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Resource and Environment, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China; Corresponding author.A versatile and environmentally friendly method for the synthesis of various organophosphorus compounds have been developed under microware conditions. We have synthesized a series of the trifluoromethyl phosphonates via Phospha-Brook rearrangement between dialkylphosphite and 3-(trifluoroacetyl)coumarins using KF/Al2O3 as a highly efficient solid catalyst under solventless conditions. Catalyst reuse, ease of separation of the pure product, and high yields are some of the unique features of this process. In addition, the mycelial growth rate method was used to examine the in vitro antifungal activities of the phosphates 4a-o against Phytophthora capsici, Fusarium oxysporum vasinfectum, Bipolaris maydis and Alternaria solani at 500 µg/mL. The results showed that compound 4n exhibited significant anti-Phytophthora capsici activity with inhibitory index of 86%.http://www.sciencedirect.com/science/article/pii/S1319610321000788Green synthesisTrifluoromethyl phosphonatesWithout solventPhospha-Brook rearrangement |
| spellingShingle | Lulu Wu Xinxin Yuan Guoyu Yang Cuilian Xu Zhenliang Pan Lijun Shi Caixia Wang Liangxin Fan An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal properties Journal of Saudi Chemical Society Green synthesis Trifluoromethyl phosphonates Without solvent Phospha-Brook rearrangement |
| title | An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal properties |
| title_full | An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal properties |
| title_fullStr | An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal properties |
| title_full_unstemmed | An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal properties |
| title_short | An eco-friendly procedure for the synthesis of new phosphates using KF/Al2O3 under solventless conditions and their antifungal properties |
| title_sort | eco friendly procedure for the synthesis of new phosphates using kf al2o3 under solventless conditions and their antifungal properties |
| topic | Green synthesis Trifluoromethyl phosphonates Without solvent Phospha-Brook rearrangement |
| url | http://www.sciencedirect.com/science/article/pii/S1319610321000788 |
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