Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus
ObjectiveThis study aims to examine the value of two-dimensional (2D) ultrasound and two-dimensional shear wave elastography (2D-SWE) in evaluating femoral nerve (FN) and saphenous nerve (SN) neuropathy in patients with type 2 diabetes mellitus (T2DM).Materials and methodsAccording to the diabetic p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.996199/full |
| _version_ | 1797990536896839680 |
|---|---|
| author | Yang Song Ying Zhang Yuhong Zhang Bin Hu |
| author_facet | Yang Song Ying Zhang Yuhong Zhang Bin Hu |
| author_sort | Yang Song |
| collection | DOAJ |
| description | ObjectiveThis study aims to examine the value of two-dimensional (2D) ultrasound and two-dimensional shear wave elastography (2D-SWE) in evaluating femoral nerve (FN) and saphenous nerve (SN) neuropathy in patients with type 2 diabetes mellitus (T2DM).Materials and methodsAccording to the diabetic peripheral neuropathy (DPN) diagnostic criteria, 60 patients with T2DM were enrolled and divided into 35 T2DM patients without DPN (non-DPN group) and 25 T2DM patients with DPN (DPN group). The control group consisted of another 15 healthy volunteers. The width, thickness, cross-sectional area (CSA), and perimeter of the FN and SN in the lower extremities were measured with 2D ultrasound. The average shear wave velocity (SWV) of the FN and SN was measured by 2D-SWE. Parameters of the left and right lower extremities were compared in each group, and the above parameters were compared among groups. The correlations between ultrasonographic and laboratory parameters were evaluated, and the independent influencing factors of SWV of the FN and SN were analyzed.ResultsThe width, thickness, CSA, perimeter, and SWV of FN and SN in the DPN group were greater than those in the non-DPN groups and control group (P < 0.05). The width, thickness, CSA, perimeter, and SWV of the FN and SN in the non-DPN group were greater than those in the control group (P < 0.05). The CSA of FN was positively correlated with FPG, HbA1c, and TG (r = 0.34–0.69, P < 0.01). The perimeter of FN was positively correlated with FPG, HbA1c, and TG (r = 0.37–0.68, P < 0.01). The perimeter of the FN was negatively correlated with IgF-1 (r = −0.31, P < 0.05). The CSA of the SN was positively correlated with FPG and TG (r = 0.26–0.42, P < 0.05). The perimeter of the SN was positively correlated with FPG and TG (r = 0.37–0.39, P < 0.01). The SWV of FN and SN were positively correlated with FPG and TG (r = 0.35–0.57, P < 0.01; r = 0.43–0.49, P < 0.01). FPG and TG were independent influencing factors of the SWV of the FN and SN (P < 0.05).Conclusion2D ultrasound and 2D-SWE could be used to non-invasively, objectively, and accurately evaluate the abnormal changes of the FN and SN in patients with T2DM. It has important clinical significance for the early diagnosis of DPN and the curative effect evaluation. |
| first_indexed | 2024-04-11T08:37:07Z |
| format | Article |
| id | doaj.art-d0d6f8e8ecc949859862898f979f356f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T08:37:07Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d0d6f8e8ecc949859862898f979f356f2022-12-22T04:34:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-10-011310.3389/fneur.2022.996199996199Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitusYang Song0Ying Zhang1Yuhong Zhang2Bin Hu3Department of Diagnostic Ultrasound, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Diagnostic Ultrasound, Xinhua Affiliated Hospital of Dalian University, Dalian, ChinaDepartment of Diagnostic Ultrasound, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Diagnostic Ultrasound, The Second Hospital of Dalian Medical University, Dalian, ChinaObjectiveThis study aims to examine the value of two-dimensional (2D) ultrasound and two-dimensional shear wave elastography (2D-SWE) in evaluating femoral nerve (FN) and saphenous nerve (SN) neuropathy in patients with type 2 diabetes mellitus (T2DM).Materials and methodsAccording to the diabetic peripheral neuropathy (DPN) diagnostic criteria, 60 patients with T2DM were enrolled and divided into 35 T2DM patients without DPN (non-DPN group) and 25 T2DM patients with DPN (DPN group). The control group consisted of another 15 healthy volunteers. The width, thickness, cross-sectional area (CSA), and perimeter of the FN and SN in the lower extremities were measured with 2D ultrasound. The average shear wave velocity (SWV) of the FN and SN was measured by 2D-SWE. Parameters of the left and right lower extremities were compared in each group, and the above parameters were compared among groups. The correlations between ultrasonographic and laboratory parameters were evaluated, and the independent influencing factors of SWV of the FN and SN were analyzed.ResultsThe width, thickness, CSA, perimeter, and SWV of FN and SN in the DPN group were greater than those in the non-DPN groups and control group (P < 0.05). The width, thickness, CSA, perimeter, and SWV of the FN and SN in the non-DPN group were greater than those in the control group (P < 0.05). The CSA of FN was positively correlated with FPG, HbA1c, and TG (r = 0.34–0.69, P < 0.01). The perimeter of FN was positively correlated with FPG, HbA1c, and TG (r = 0.37–0.68, P < 0.01). The perimeter of the FN was negatively correlated with IgF-1 (r = −0.31, P < 0.05). The CSA of the SN was positively correlated with FPG and TG (r = 0.26–0.42, P < 0.05). The perimeter of the SN was positively correlated with FPG and TG (r = 0.37–0.39, P < 0.01). The SWV of FN and SN were positively correlated with FPG and TG (r = 0.35–0.57, P < 0.01; r = 0.43–0.49, P < 0.01). FPG and TG were independent influencing factors of the SWV of the FN and SN (P < 0.05).Conclusion2D ultrasound and 2D-SWE could be used to non-invasively, objectively, and accurately evaluate the abnormal changes of the FN and SN in patients with T2DM. It has important clinical significance for the early diagnosis of DPN and the curative effect evaluation.https://www.frontiersin.org/articles/10.3389/fneur.2022.996199/fullperipheral neuropathyfemoral nervesaphenous nervediabetestype 2ultrasonography |
| spellingShingle | Yang Song Ying Zhang Yuhong Zhang Bin Hu Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus Frontiers in Neurology peripheral neuropathy femoral nerve saphenous nerve diabetes type 2 ultrasonography |
| title | Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus |
| title_full | Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus |
| title_fullStr | Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus |
| title_short | Two-dimensional ultrasound and two-dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus |
| title_sort | two dimensional ultrasound and two dimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus |
| topic | peripheral neuropathy femoral nerve saphenous nerve diabetes type 2 ultrasonography |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.996199/full |
| work_keys_str_mv | AT yangsong twodimensionalultrasoundandtwodimensionalshearwaveelastographyonfemoralandsaphenousneuropathyinpatientswithtype2diabetesmellitus AT yingzhang twodimensionalultrasoundandtwodimensionalshearwaveelastographyonfemoralandsaphenousneuropathyinpatientswithtype2diabetesmellitus AT yuhongzhang twodimensionalultrasoundandtwodimensionalshearwaveelastographyonfemoralandsaphenousneuropathyinpatientswithtype2diabetesmellitus AT binhu twodimensionalultrasoundandtwodimensionalshearwaveelastographyonfemoralandsaphenousneuropathyinpatientswithtype2diabetesmellitus |