FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells

FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells

Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferation, survival, and metastasis, mitochondria highlight as an important target for anticancer drug discovery. FRI-1, methyl 1, 3-dimethyl-5, 8-dioxo-5, 8-dihydro-4-isoquinolinecarboxylate, was previousl...

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Bibliographic Details
Main Authors: Miguel Córdova-Delgado, Sebastián Fuentes-Retamal, Charlotte Palominos, Camila López-Torres, Daniela Guzmán-Rivera, Oney Ramírez-Rodríguez, Ramiro Araya-Maturana, Félix A. Urra
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Antioxidants
Subjects:
tricarboxylic acid (TCA) cycle
mitochondria
mitocans
2-oxoglutarate dehydrogenase (OGDH)
AMP-activated kinase (AMPK) signaling
CPI-613
Online Access:https://www.mdpi.com/2076-3921/10/10/1618

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