Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide
Abstract Background Atrial natriuretic peptide (ANP) is a cardiovascular and metabolic hormone that has been identified recently as being associated with chronic kidney disease (CKD) without diabetes. Cytokines such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin (ADP) contr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-021-00867-7 |
| _version_ | 1818841734603341824 |
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| author | Chenxiao Liu Qi Li Xiu Feng Jian Zhu Qian Li |
| author_facet | Chenxiao Liu Qi Li Xiu Feng Jian Zhu Qian Li |
| author_sort | Chenxiao Liu |
| collection | DOAJ |
| description | Abstract Background Atrial natriuretic peptide (ANP) is a cardiovascular and metabolic hormone that has been identified recently as being associated with chronic kidney disease (CKD) without diabetes. Cytokines such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin (ADP) contribute to the development of type 2 diabetes (T2DM). The aim here was to investigate the relationships of ANP with cytokine levels and clinical variables in T2DM nephropathy patients. Methods A total of 81 participants with T2DM were recruited, including 37 patients with normoalbuminuria, 23 patients with microalbuminuria and 21 patients with macroalbuminuria. Serum concentrations of ANP and cytokines were measured using enzyme-linked immunosorbent assay (ELISA) kits. The correlations between ANP and clinical variables were analyzed. Multiple linear regression and logistic regression models were constructed to test the associations between ANP and the severity and presence of albuminuria. Results The macroalbuminuria patients exhibited higher plasma levels of ANP, TNF-α, IL-6, and ADP; higher serum creatinine (Cr) and blood urea nitrogen (BUN); and longer duration of diabetes mellitus (DM) than the patients with normoalbuminuria and microalbuminuria. Plasma ANP level was significantly associated with TNF-α (r = 0.876, p < 0.001), IL-6 (r = 0.816, p < 0.001) and ADP (r = 0.772, p < 0.001), independent of the duration of DM or the BUN concentration. Conclusion ANP is higher in type 2 diabetes mellitus nephropathy subjects, especially those who have macroalbuminuria, which is associated with compensatory responses to inflammation. |
| first_indexed | 2024-12-19T04:30:47Z |
| format | Article |
| id | doaj.art-d0d89c06464b454787d360576dd82a9c |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-19T04:30:47Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-d0d89c06464b454787d360576dd82a9c2022-12-21T20:35:53ZengBMCBMC Endocrine Disorders1472-68232021-10-012111810.1186/s12902-021-00867-7Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptideChenxiao Liu0Qi Li1Xiu Feng2Jian Zhu3Qian Li4Department of Endocrinology, Suzhou Municipal Hospital, Nanjing Medical UniversityDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Endocrinology, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow UniversityDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical UniversityAbstract Background Atrial natriuretic peptide (ANP) is a cardiovascular and metabolic hormone that has been identified recently as being associated with chronic kidney disease (CKD) without diabetes. Cytokines such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin (ADP) contribute to the development of type 2 diabetes (T2DM). The aim here was to investigate the relationships of ANP with cytokine levels and clinical variables in T2DM nephropathy patients. Methods A total of 81 participants with T2DM were recruited, including 37 patients with normoalbuminuria, 23 patients with microalbuminuria and 21 patients with macroalbuminuria. Serum concentrations of ANP and cytokines were measured using enzyme-linked immunosorbent assay (ELISA) kits. The correlations between ANP and clinical variables were analyzed. Multiple linear regression and logistic regression models were constructed to test the associations between ANP and the severity and presence of albuminuria. Results The macroalbuminuria patients exhibited higher plasma levels of ANP, TNF-α, IL-6, and ADP; higher serum creatinine (Cr) and blood urea nitrogen (BUN); and longer duration of diabetes mellitus (DM) than the patients with normoalbuminuria and microalbuminuria. Plasma ANP level was significantly associated with TNF-α (r = 0.876, p < 0.001), IL-6 (r = 0.816, p < 0.001) and ADP (r = 0.772, p < 0.001), independent of the duration of DM or the BUN concentration. Conclusion ANP is higher in type 2 diabetes mellitus nephropathy subjects, especially those who have macroalbuminuria, which is associated with compensatory responses to inflammation.https://doi.org/10.1186/s12902-021-00867-7Atrial natriuretic peptideType 2 diabetesDiabetic nephropathyAlbuminuriaCytokines |
| spellingShingle | Chenxiao Liu Qi Li Xiu Feng Jian Zhu Qian Li Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide BMC Endocrine Disorders Atrial natriuretic peptide Type 2 diabetes Diabetic nephropathy Albuminuria Cytokines |
| title | Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide |
| title_full | Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide |
| title_fullStr | Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide |
| title_full_unstemmed | Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide |
| title_short | Deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide |
| title_sort | deterioration of diabetic nephropathy via stimulating secretion of cytokines by atrial natriuretic peptide |
| topic | Atrial natriuretic peptide Type 2 diabetes Diabetic nephropathy Albuminuria Cytokines |
| url | https://doi.org/10.1186/s12902-021-00867-7 |
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