Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessment
Assessment of cerebral perfusion in patients with acute ischemic stroke by means of perfusion CT (PCT) allows retrievingquantitative data on the cerebral blood flow (CBF), cerebralblood volume (CBV) and mean transit time (MTT). Thirtypatients at earliest stages (first 24 hrs) of ischemic supratentor...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
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| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/360/259 |
| _version_ | 1818240603980300288 |
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| author | D. V. Sergeev M. V. Krotenkova M. A. Piradov |
| author_facet | D. V. Sergeev M. V. Krotenkova M. A. Piradov |
| author_sort | D. V. Sergeev |
| collection | DOAJ |
| description | Assessment of cerebral perfusion in patients with acute ischemic stroke by means of perfusion CT (PCT) allows retrievingquantitative data on the cerebral blood flow (CBF), cerebralblood volume (CBV) and mean transit time (MTT). Thirtypatients at earliest stages (first 24 hrs) of ischemic supratentorial stroke were studied, of whom patients with moderate tosevere stroke predominated (median NIHSS score of 11.5).PCT was performed on day 1, 3 and 10, and diffusion-weighted MRI (DWI) on day 1. It was shown that cerebral ischemia inthe acute stage was characterized by the decrease of CBF andCBV (10.0 ml/100g х min and 1.9 ml/100 g, respectively), and
the increase of MTT (11.3 s). CBV lesion correlates well withthe DWI lesion (r=0.91), i.e. with irreversible ischemic tissuedamage, and its size is smaller than the sizes of CBF and MTTlesions. This mismatch reflects the penumbra zone. Theinfarct core has decreased CBF and CBV, and elevated MTT,while the penumbral tissue has only decreased CBF and elevated MTT when compared to the normal hemisphere. Thepenumbra and the core differ by values of CBF and CBV,but this difference is shaded by day 3. Increase of CBV in theinfarct core in the course of stroke indicates the restorationof blood flow. A prognostic index is elaborated which allows
predicting the transformation of ischemia into irreversible tissue damage: it is the decrease of CBV for more than 12% copared with the intact hemisphere. |
| first_indexed | 2024-12-12T13:16:05Z |
| format | Article |
| id | doaj.art-d0dbd55fef424b2a8354626c89a7b4c5 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T13:16:05Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-d0dbd55fef424b2a8354626c89a7b4c52022-12-22T00:23:25ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0134192810.17816/psaic360259Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessmentD. V. Sergeev0M. V. Krotenkova1M. A. Piradov2Research Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowAssessment of cerebral perfusion in patients with acute ischemic stroke by means of perfusion CT (PCT) allows retrievingquantitative data on the cerebral blood flow (CBF), cerebralblood volume (CBV) and mean transit time (MTT). Thirtypatients at earliest stages (first 24 hrs) of ischemic supratentorial stroke were studied, of whom patients with moderate tosevere stroke predominated (median NIHSS score of 11.5).PCT was performed on day 1, 3 and 10, and diffusion-weighted MRI (DWI) on day 1. It was shown that cerebral ischemia inthe acute stage was characterized by the decrease of CBF andCBV (10.0 ml/100g х min and 1.9 ml/100 g, respectively), and the increase of MTT (11.3 s). CBV lesion correlates well withthe DWI lesion (r=0.91), i.e. with irreversible ischemic tissuedamage, and its size is smaller than the sizes of CBF and MTTlesions. This mismatch reflects the penumbra zone. Theinfarct core has decreased CBF and CBV, and elevated MTT,while the penumbral tissue has only decreased CBF and elevated MTT when compared to the normal hemisphere. Thepenumbra and the core differ by values of CBF and CBV,but this difference is shaded by day 3. Increase of CBV in theinfarct core in the course of stroke indicates the restorationof blood flow. A prognostic index is elaborated which allows predicting the transformation of ischemia into irreversible tissue damage: it is the decrease of CBV for more than 12% copared with the intact hemisphere.https://annaly-nevrologii.com/journal/pathID/article/viewFile/360/259ischemic strokecerebral perfusionperfusion ctdiffusionweighted mri |
| spellingShingle | D. V. Sergeev M. V. Krotenkova M. A. Piradov Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessment Анналы клинической и экспериментальной неврологии ischemic stroke cerebral perfusion perfusion ct diffusion weighted mri |
| title | Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessment |
| title_full | Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessment |
| title_fullStr | Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessment |
| title_full_unstemmed | Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessment |
| title_short | Cerebral perfusion in the acute ischemic stroke: clinical and CT-perfusion assessment |
| title_sort | cerebral perfusion in the acute ischemic stroke clinical and ct perfusion assessment |
| topic | ischemic stroke cerebral perfusion perfusion ct diffusion weighted mri |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/360/259 |
| work_keys_str_mv | AT dvsergeev cerebralperfusionintheacuteischemicstrokeclinicalandctperfusionassessment AT mvkrotenkova cerebralperfusionintheacuteischemicstrokeclinicalandctperfusionassessment AT mapiradov cerebralperfusionintheacuteischemicstrokeclinicalandctperfusionassessment |