Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin Deficiency
To explore the ingredients and possible mechanisms of Mulberry for controlling coronary heart disease of liver and kidney yin deficiency based on network pharmacology and molecular docking. The active components and common targets of Mulberry combating coronary heart disease of liver and kidney yin...
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| Format: | Article |
| Language: | English |
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Academy of National Food and Strategic Reserves Administration
2022-05-01
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| Series: | Liang you shipin ke-ji |
| Subjects: | |
| Online Access: | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20220322?st=article_issue |
| _version_ | 1797867003669643264 |
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| author | SONG Xiao-man LI Wen-lin YANG Li-li ZENG Li |
| author_facet | SONG Xiao-man LI Wen-lin YANG Li-li ZENG Li |
| author_sort | SONG Xiao-man |
| collection | DOAJ |
| description | To explore the ingredients and possible mechanisms of Mulberry for controlling coronary heart disease of liver and kidney yin deficiency based on network pharmacology and molecular docking. The active components and common targets of Mulberry combating coronary heart disease of liver and kidney yin deficiency were obtained from TCMSP, TCMID, Swiss TargetPrediction, and GeneCards databases; cytoscape software was used to generate component-target-disease interaction network diagram. PPI network was constructed and analyzed by STRING database; with the help of DAVID database, the GO function analysis and KEGG pathway enrichment analysis were carried out, and finally Schrödinger Maestro was used to verify the molecular docking of main active ingredients and key targets. There were 14 active components in Mulberry, and 134 target genes were associated with coronary heart disease of liver and kidney yin deficiency. Predicted target genes mainly acted on TNF, PI3K/AKT signaling pathways to prevent and treat coronary heart disease with liver and kidney yin deficiency by regulating inflammation, apoptosis and blood circulation. Molecular docking results showed that the main active ingredients had good binding properties with candidate target proteins. The study preliminarily reveals that Mulberry can prevent and treat coronary heart disease of liver and kidney yin deficiency through multi- components, multi-targets and multi-pathways. The results can provide theoretical reference and new research direction for the development of Mulberry and functional foods for controlling the coronary heart disease of liver and kidney yin deficiency. |
| first_indexed | 2024-04-09T23:33:25Z |
| format | Article |
| id | doaj.art-d0dbe30939f9485d90a5d7b7e66afd04 |
| institution | Directory Open Access Journal |
| issn | 1007-7561 |
| language | English |
| last_indexed | 2024-04-09T23:33:25Z |
| publishDate | 2022-05-01 |
| publisher | Academy of National Food and Strategic Reserves Administration |
| record_format | Article |
| series | Liang you shipin ke-ji |
| spelling | doaj.art-d0dbe30939f9485d90a5d7b7e66afd042023-03-21T02:26:05ZengAcademy of National Food and Strategic Reserves AdministrationLiang you shipin ke-ji1007-75612022-05-0130313714710.16210/j.cnki.1007-7561.2022.03.015Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin DeficiencySONG Xiao-man0LI Wen-lin1YANG Li-li2ZENG Li3College of Acupuncture, Massage, Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaCollege of Acupuncture, Massage, Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China; Jingwen Library, Collaborative Innovation Center for the Industrialization Process of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaJingwen Library, Collaborative Innovation Center for the Industrialization Process of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China; School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaSchool of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaTo explore the ingredients and possible mechanisms of Mulberry for controlling coronary heart disease of liver and kidney yin deficiency based on network pharmacology and molecular docking. The active components and common targets of Mulberry combating coronary heart disease of liver and kidney yin deficiency were obtained from TCMSP, TCMID, Swiss TargetPrediction, and GeneCards databases; cytoscape software was used to generate component-target-disease interaction network diagram. PPI network was constructed and analyzed by STRING database; with the help of DAVID database, the GO function analysis and KEGG pathway enrichment analysis were carried out, and finally Schrödinger Maestro was used to verify the molecular docking of main active ingredients and key targets. There were 14 active components in Mulberry, and 134 target genes were associated with coronary heart disease of liver and kidney yin deficiency. Predicted target genes mainly acted on TNF, PI3K/AKT signaling pathways to prevent and treat coronary heart disease with liver and kidney yin deficiency by regulating inflammation, apoptosis and blood circulation. Molecular docking results showed that the main active ingredients had good binding properties with candidate target proteins. The study preliminarily reveals that Mulberry can prevent and treat coronary heart disease of liver and kidney yin deficiency through multi- components, multi-targets and multi-pathways. The results can provide theoretical reference and new research direction for the development of Mulberry and functional foods for controlling the coronary heart disease of liver and kidney yin deficiency.http://lyspkj.ijournal.cn/lyspkj/article/abstract/20220322?st=article_issuemulberrycoronary heart diseaseliver and kidney yin deficiencynetwork pharmacologymolecular dockingmechanism |
| spellingShingle | SONG Xiao-man LI Wen-lin YANG Li-li ZENG Li Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin Deficiency Liang you shipin ke-ji mulberry coronary heart disease liver and kidney yin deficiency network pharmacology molecular docking mechanism |
| title | Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin Deficiency |
| title_full | Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin Deficiency |
| title_fullStr | Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin Deficiency |
| title_full_unstemmed | Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin Deficiency |
| title_short | Research on the Ingredients and Mechanisms of Mulberry in the Prevention and Treatment of Coronary Heart Disease of Liver and Kidney Yin Deficiency |
| title_sort | research on the ingredients and mechanisms of mulberry in the prevention and treatment of coronary heart disease of liver and kidney yin deficiency |
| topic | mulberry coronary heart disease liver and kidney yin deficiency network pharmacology molecular docking mechanism |
| url | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20220322?st=article_issue |
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