K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot Study
<i>Escherichia coli</i> is responsible for diseases of varying severity. The “K” antigen designates the capsular polysaccharides on the bacterial surface, which are mostly similar to those of highly pathogenic bacteria. The K1 antigen is often found in pathogenic <i>E. coli</i&g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/9/1884 |
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| author | Maelys Proquot Lovasoa Najaraly Jamal Chloe Plouzeau-Jayle Anthony Michaud Lauranne Broutin Christophe Burucoa Julie Cremniter Maxime Pichon |
| author_facet | Maelys Proquot Lovasoa Najaraly Jamal Chloe Plouzeau-Jayle Anthony Michaud Lauranne Broutin Christophe Burucoa Julie Cremniter Maxime Pichon |
| author_sort | Maelys Proquot |
| collection | DOAJ |
| description | <i>Escherichia coli</i> is responsible for diseases of varying severity. The “K” antigen designates the capsular polysaccharides on the bacterial surface, which are mostly similar to those of highly pathogenic bacteria. The K1 antigen is often found in pathogenic <i>E. coli</i>. Aim: While the published studies on the AST profile of K1-positive <i>E. coli</i> have focused on pregnant women or newborns, this study aimed to characterize the AST profile of K1-positive <i>E. coli</i> independently of the clinical sample of isolation. Over a 4-week-long period, all patients hospitalized/consulting at the Poitiers University Hospital presenting a determined AST on <i>E. coli</i> were prospectively included to define their K1-status (Pastorex Meningitis) and to collect the clinical (age/sex) or biological metadata (AST/MIC). Among the 296 included samples, no differential representation was observed between K1 results regarding sample nature. K1-negative results were associated with multiple antibiotic-resistance (12.3% vs. 33.0%; <i>p</i> < 0.01). AST phenotypes differed between these groups, with a higher proportion of K1-negativity among resistant strains, especially on β-lactams (ureidopenicillin, 25.8% vs. 14.9%; and ampicillin/inhibitor, 50.0% vs. 26.8%; <i>p</i> < 0.05) or quinolone (19.8% vs. 7.0%) and sulfamethoxazole-trimethoprim (30.2% vs. 12.3%) (<i>p</i> < 0.01). This study analyzed <i>E. coli</i> ASTs in clinical samples of all types, regarding their K1-antigen status. |
| first_indexed | 2024-03-10T07:25:30Z |
| format | Article |
| id | doaj.art-d0df31d797734ca88526206c54d76f0e |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T07:25:30Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d0df31d797734ca88526206c54d76f0e2023-11-22T14:18:35ZengMDPI AGMicroorganisms2076-26072021-09-0199188410.3390/microorganisms9091884K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot StudyMaelys Proquot0Lovasoa Najaraly Jamal1Chloe Plouzeau-Jayle2Anthony Michaud3Lauranne Broutin4Christophe Burucoa5Julie Cremniter6Maxime Pichon7Bacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, FranceBacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, FranceBacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, FranceBacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, FranceBacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, FranceBacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, FranceBacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, FranceBacteriology and Infection Control Laboratory, Infectious Agents Department, University Hospital of Poitiers, 86021 Poitiers, France<i>Escherichia coli</i> is responsible for diseases of varying severity. The “K” antigen designates the capsular polysaccharides on the bacterial surface, which are mostly similar to those of highly pathogenic bacteria. The K1 antigen is often found in pathogenic <i>E. coli</i>. Aim: While the published studies on the AST profile of K1-positive <i>E. coli</i> have focused on pregnant women or newborns, this study aimed to characterize the AST profile of K1-positive <i>E. coli</i> independently of the clinical sample of isolation. Over a 4-week-long period, all patients hospitalized/consulting at the Poitiers University Hospital presenting a determined AST on <i>E. coli</i> were prospectively included to define their K1-status (Pastorex Meningitis) and to collect the clinical (age/sex) or biological metadata (AST/MIC). Among the 296 included samples, no differential representation was observed between K1 results regarding sample nature. K1-negative results were associated with multiple antibiotic-resistance (12.3% vs. 33.0%; <i>p</i> < 0.01). AST phenotypes differed between these groups, with a higher proportion of K1-negativity among resistant strains, especially on β-lactams (ureidopenicillin, 25.8% vs. 14.9%; and ampicillin/inhibitor, 50.0% vs. 26.8%; <i>p</i> < 0.05) or quinolone (19.8% vs. 7.0%) and sulfamethoxazole-trimethoprim (30.2% vs. 12.3%) (<i>p</i> < 0.01). This study analyzed <i>E. coli</i> ASTs in clinical samples of all types, regarding their K1-antigen status.https://www.mdpi.com/2076-2607/9/9/1884<i>Escherichia coli</i>K1 antigenvirulencematernal-fetal infectionantibiotic susceptibility testingresistance to antimicrobial agents |
| spellingShingle | Maelys Proquot Lovasoa Najaraly Jamal Chloe Plouzeau-Jayle Anthony Michaud Lauranne Broutin Christophe Burucoa Julie Cremniter Maxime Pichon K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot Study Microorganisms <i>Escherichia coli</i> K1 antigen virulence maternal-fetal infection antibiotic susceptibility testing resistance to antimicrobial agents |
| title | K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot Study |
| title_full | K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot Study |
| title_fullStr | K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot Study |
| title_full_unstemmed | K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot Study |
| title_short | K1 Antigen Is Associated with Different AST Profile in <i>Escherichia coli</i>: A One-Month-Long Pilot Study |
| title_sort | k1 antigen is associated with different ast profile in i escherichia coli i a one month long pilot study |
| topic | <i>Escherichia coli</i> K1 antigen virulence maternal-fetal infection antibiotic susceptibility testing resistance to antimicrobial agents |
| url | https://www.mdpi.com/2076-2607/9/9/1884 |
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