Human adipose ECM alleviates radiation-induced skin fibrosis via endothelial cell-mediated M2 macrophage polarization

Human adipose ECM alleviates radiation-induced skin fibrosis via endothelial cell-mediated M2 macrophage polarization

Summary: Radiation therapy can lead to late radiation-induced skin fibrosis (RISF), causing movement restriction, pain, and organ dysfunction. This study evaluated adipose-derived extracellular matrix (Ad-ECM) as a mitigator of RISF. Female C57BL/6J mice that were irradiated developed fibrosis, whic...

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Bibliographic Details
Main Authors: Somaiah Chinnapaka, Katherine S. Yang, Yusuf Surucu, Fuat B. Bengur, José A. Arellano, Zayaan Tirmizi, Hamid Malekzadeh, Michael W. Epperly, Wen Hou, Joel S. Greenberger, J. Peter Rubin, Asim Ejaz
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Cell biology
Dermatology
Fibrosis
Immunology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223017376

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