Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder

Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder

Bipolar disorder (BD) is a chronic mental illness characterized by mood fluctuations that range from depressive lows to manic highs. Several studies have linked the downregulation of SIRT-1 (silent mating type information regulation-2 homologs) signaling to the onset of BD and other neurological dys...

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Bibliographic Details
Main Authors: Bidisha Rajkhowa, Sidharth Mehan, Pranshul Sethi, Aradhana Prajapati, Manisha Suri, Sumit Kumar, Sonalika Bhalla, Acharan S. Narula, Abdulrahman Alshammari, Metab Alharbi, Nora Alkahtani, Saeed Alghamdi, Reni Kalfin
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
bipolar disorder
lithium
neuroprotection
ouabain
SIRT-1
solanesol
Online Access:https://www.mdpi.com/1424-8247/15/8/959

Internet

https://www.mdpi.com/1424-8247/15/8/959

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