Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study
Abstract Evidence suggests that iron status may be linked to symptoms of childhood attention deficit/hyperactivity disorder (ADHD), but there is little data available on the relationship between iron status in pregnancy and the risk of developing ADHD. And the data that does exist is inconsistent. O...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23432-1 |
| _version_ | 1811315434447699968 |
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| author | Andrés Díaz-López Josefa Canals Sans Jordi Julvez Silvia Fernandez-Bares Sabrina Llop Marisa Rebagliato Nerea Lertxundi Loreto Santa-Marina Mònica Guxens Jordi Sunyer Victoria Arija |
| author_facet | Andrés Díaz-López Josefa Canals Sans Jordi Julvez Silvia Fernandez-Bares Sabrina Llop Marisa Rebagliato Nerea Lertxundi Loreto Santa-Marina Mònica Guxens Jordi Sunyer Victoria Arija |
| author_sort | Andrés Díaz-López |
| collection | DOAJ |
| description | Abstract Evidence suggests that iron status may be linked to symptoms of childhood attention deficit/hyperactivity disorder (ADHD), but there is little data available on the relationship between iron status in pregnancy and the risk of developing ADHD. And the data that does exist is inconsistent. Our aim here is to assess the effect of maternal serum ferritin (SF) and haemoglobin (Hb) levels during pregnancy on manifestations of ADHD in children at 7 years of age. This prospective study analysed data from 1204 mother–child pairs from three Spanish cohorts participating in the INMA project. Maternal SF and Hb levels during pregnancy and other mother and child characteristics were collected. The children’s ADHD behaviours were reported by their parents using Conners’ Parent Rating Scale-Revised Short Form (CPRS-R:S). In the unadjusted regression analysis, maternal SF was positively associated with children’s T-scores on the subscales Cognitive problems/Inattention (β: 0.63, 95%CI 0.06–1.19; p = 0.029) and ADHD index (β: 0.72, 95%CI 0.20–1.24; p = 0.007). These associations were not present after multivariate adjustment or stratification by first and second trimester of pregnancy. The Hb levels were not related to any of the CPRS-R:S subscales in unadjusted or multivariate-adjusted models. We observed no association between maternal SF or Hb levels and the risk of ADHD symptomatology (T-score ≥ 65 for CPRS-R:S subscales). Our results suggest that neither maternal SF nor Hb levels during pregnancy are related to ADHD symptoms in 7-year-old children. |
| first_indexed | 2024-04-13T11:30:08Z |
| format | Article |
| id | doaj.art-d0e0c8b5e1df44a9a0e922b32b31659e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T11:30:08Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d0e0c8b5e1df44a9a0e922b32b31659e2022-12-22T02:48:35ZengNature PortfolioScientific Reports2045-23222022-12-0112111110.1038/s41598-022-23432-1Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort studyAndrés Díaz-López0Josefa Canals Sans1Jordi Julvez2Silvia Fernandez-Bares3Sabrina Llop4Marisa Rebagliato5Nerea Lertxundi6Loreto Santa-Marina7Mònica Guxens8Jordi Sunyer9Victoria Arija10Department of Basic Medical Sciences, Nutrition and Mental Health Research Group (NUTRISAM), Rovira I Virgili University (URV)Department of Basic Medical Sciences, Nutrition and Mental Health Research Group (NUTRISAM), Rovira I Virgili University (URV)Institut d’Investigació Sanitària Pere Virgili (IISPV)Barcelona Institute for Global Health (ISGlobal)Epidemiology and Environmental Health Joint Research Unit, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de ValènciaEpidemiology and Environmental Health Joint Research Unit, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de ValènciaSpanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos IIISpanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos IIIBarcelona Institute for Global Health (ISGlobal)Barcelona Institute for Global Health (ISGlobal)Department of Basic Medical Sciences, Nutrition and Mental Health Research Group (NUTRISAM), Rovira I Virgili University (URV)Abstract Evidence suggests that iron status may be linked to symptoms of childhood attention deficit/hyperactivity disorder (ADHD), but there is little data available on the relationship between iron status in pregnancy and the risk of developing ADHD. And the data that does exist is inconsistent. Our aim here is to assess the effect of maternal serum ferritin (SF) and haemoglobin (Hb) levels during pregnancy on manifestations of ADHD in children at 7 years of age. This prospective study analysed data from 1204 mother–child pairs from three Spanish cohorts participating in the INMA project. Maternal SF and Hb levels during pregnancy and other mother and child characteristics were collected. The children’s ADHD behaviours were reported by their parents using Conners’ Parent Rating Scale-Revised Short Form (CPRS-R:S). In the unadjusted regression analysis, maternal SF was positively associated with children’s T-scores on the subscales Cognitive problems/Inattention (β: 0.63, 95%CI 0.06–1.19; p = 0.029) and ADHD index (β: 0.72, 95%CI 0.20–1.24; p = 0.007). These associations were not present after multivariate adjustment or stratification by first and second trimester of pregnancy. The Hb levels were not related to any of the CPRS-R:S subscales in unadjusted or multivariate-adjusted models. We observed no association between maternal SF or Hb levels and the risk of ADHD symptomatology (T-score ≥ 65 for CPRS-R:S subscales). Our results suggest that neither maternal SF nor Hb levels during pregnancy are related to ADHD symptoms in 7-year-old children.https://doi.org/10.1038/s41598-022-23432-1 |
| spellingShingle | Andrés Díaz-López Josefa Canals Sans Jordi Julvez Silvia Fernandez-Bares Sabrina Llop Marisa Rebagliato Nerea Lertxundi Loreto Santa-Marina Mònica Guxens Jordi Sunyer Victoria Arija Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study Scientific Reports |
| title | Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study |
| title_full | Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study |
| title_fullStr | Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study |
| title_full_unstemmed | Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study |
| title_short | Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study |
| title_sort | maternal iron status during pregnancy and attention deficit hyperactivity disorder symptoms in 7 year old children a prospective cohort study |
| url | https://doi.org/10.1038/s41598-022-23432-1 |
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