Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations
In spite of current treatment strategies, myocardial infarction and stroke are still major causes of death worldwide. These events are triggered by damage of an atherosclerotic plaque, resulting in occlusive thrombus formation. Mouse studies have significantly contributed to our understanding of the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-05-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2019.1708884 |
| _version_ | 1797684226967994368 |
|---|---|
| author | MFA Karel B. Hechler MJE Kuijpers JMEM Cosemans |
| author_facet | MFA Karel B. Hechler MJE Kuijpers JMEM Cosemans |
| author_sort | MFA Karel |
| collection | DOAJ |
| description | In spite of current treatment strategies, myocardial infarction and stroke are still major causes of death worldwide. These events are triggered by damage of an atherosclerotic plaque, resulting in occlusive thrombus formation. Mouse studies have significantly contributed to our understanding of the mechanisms of atherogenesis and of thrombosis following plaque injury, but the extent to which the mouse serves as an accurate model of human disease is open to discussion. In this review, we provide a detailed overview and comparison of the described mouse models for atherothrombosis including their (dis)advantages. Herein guidance is provided on how to select a suitable atherothrombosis model for research questions primarily relevant to the field of thrombosis. |
| first_indexed | 2024-03-12T00:26:36Z |
| format | Article |
| id | doaj.art-d0e17a3ac0b34639a23f621a5b02e38d |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:36Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-d0e17a3ac0b34639a23f621a5b02e38d2023-09-15T10:32:02ZengTaylor & Francis GroupPlatelets0953-71041369-16352020-05-0131443944610.1080/09537104.2019.17088841708884Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitationsMFA Karel0B. Hechler1MJE Kuijpers2JMEM Cosemans3Cardiovascular Research Institute Maastricht (CARIM), Maastricht UniversityUniversité de Strasbourg, INSERM, Etablissement Français du Sang (EFS)-Grand Est, BPPS UMR_S 1255, Fédération de Médecine Translationnelle de Strasbourg (FMTS)Cardiovascular Research Institute Maastricht (CARIM), Maastricht UniversityCardiovascular Research Institute Maastricht (CARIM), Maastricht UniversityIn spite of current treatment strategies, myocardial infarction and stroke are still major causes of death worldwide. These events are triggered by damage of an atherosclerotic plaque, resulting in occlusive thrombus formation. Mouse studies have significantly contributed to our understanding of the mechanisms of atherogenesis and of thrombosis following plaque injury, but the extent to which the mouse serves as an accurate model of human disease is open to discussion. In this review, we provide a detailed overview and comparison of the described mouse models for atherothrombosis including their (dis)advantages. Herein guidance is provided on how to select a suitable atherothrombosis model for research questions primarily relevant to the field of thrombosis.http://dx.doi.org/10.1080/09537104.2019.1708884atherosclerosiscoagulationmurine atherothrombosisplaque erosionplaque ruptureplatelets |
| spellingShingle | MFA Karel B. Hechler MJE Kuijpers JMEM Cosemans Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations Platelets atherosclerosis coagulation murine atherothrombosis plaque erosion plaque rupture platelets |
| title | Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations |
| title_full | Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations |
| title_fullStr | Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations |
| title_full_unstemmed | Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations |
| title_short | Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations |
| title_sort | atherosclerotic plaque injury mediated murine thrombosis models advantages and limitations |
| topic | atherosclerosis coagulation murine atherothrombosis plaque erosion plaque rupture platelets |
| url | http://dx.doi.org/10.1080/09537104.2019.1708884 |
| work_keys_str_mv | AT mfakarel atheroscleroticplaqueinjurymediatedmurinethrombosismodelsadvantagesandlimitations AT bhechler atheroscleroticplaqueinjurymediatedmurinethrombosismodelsadvantagesandlimitations AT mjekuijpers atheroscleroticplaqueinjurymediatedmurinethrombosismodelsadvantagesandlimitations AT jmemcosemans atheroscleroticplaqueinjurymediatedmurinethrombosismodelsadvantagesandlimitations |