Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis
Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2012-11-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.8.232 |
| _version_ | 1818733767221575680 |
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| author | Jian Yin Steffen Eller Mayeul Collot Peter H. Seeberger |
| author_facet | Jian Yin Steffen Eller Mayeul Collot Peter H. Seeberger |
| author_sort | Jian Yin |
| collection | DOAJ |
| description | Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis. |
| first_indexed | 2024-12-17T23:54:42Z |
| format | Article |
| id | doaj.art-d0e3aeca888d4a7e81eda2163c025629 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-17T23:54:42Z |
| publishDate | 2012-11-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-d0e3aeca888d4a7e81eda2163c0256292022-12-21T21:28:05ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972012-11-01812067207110.3762/bjoc.8.2321860-5397-8-232Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesisJian Yin0Steffen Eller1Mayeul Collot2Peter H. Seeberger3Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanyDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanyDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanyDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanySafety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis.https://doi.org/10.3762/bjoc.8.232glycosaminoglycans (GAGs)glycosylationresinssafety-catch linkersolid-phase synthesis |
| spellingShingle | Jian Yin Steffen Eller Mayeul Collot Peter H. Seeberger Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis Beilstein Journal of Organic Chemistry glycosaminoglycans (GAGs) glycosylation resins safety-catch linker solid-phase synthesis |
| title | Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis |
| title_full | Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis |
| title_fullStr | Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis |
| title_full_unstemmed | Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis |
| title_short | Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis |
| title_sort | acylsulfonamide safety catch linker promise and limitations for solid phase oligosaccharide synthesis |
| topic | glycosaminoglycans (GAGs) glycosylation resins safety-catch linker solid-phase synthesis |
| url | https://doi.org/10.3762/bjoc.8.232 |
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