Synthesis and Biological Studies on (KLAKLAK)<sub>2</sub>-NH<sub>2</sub> Analog Containing Unnatural Amino Acid β-Ala and Conjugates with Second Pharmacophore

Synthesis and Biological Studies on (KLAKLAK)<sub>2</sub>-NH<sub>2</sub> Analog Containing Unnatural Amino Acid β-Ala and Conjugates with Second Pharmacophore

(1) Background: Peptides are good candidates for anticancer drugs due to their natural existence in the body and lack of secondary effects. (KLAKLAK)<sub>2</sub> is an antimicrobial peptide that also shows good anticancer properties. (2) Methods: The Solid Phase Peptide Synthesis (Fmoc-s...

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Bibliographic Details
Main Authors: Sirine Jaber, Veronica Nemska, Ivan Iliev, Elena Ivanova, Tsvetelina Foteva, Nelly Georgieva, Ivan Givechev, Emilia Naydenova, Veronika Karadjova, Dancho Danalev
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
(KLAKLAK)<sub>2</sub>
antitumor peptides
1,8-naphthalimide
caffeic acid
unnatural amino acids
Online Access:https://www.mdpi.com/1420-3049/26/23/7321

Internet

https://www.mdpi.com/1420-3049/26/23/7321

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