Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis

Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis

It has been shown that dexmedetomidine (Dex) could attenuate postoperative cognitive dysfunction (POCD) via targeting circular RNAs (circRNAs). Circ-Shank3 has been found to be involved in the neuroprotective effects of Dex against POCD. However, the role of circ-Shank3 in POCD remains largely unkn...

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Bibliographic Details
Main Authors: Guangbao He, Yibo He, Hongwei Ni, Kai Wang, Yijun Zhu, Yang Bao
Format: Article
Language:English
Published: PAGEPress Publications 2023-07-01
Series:European Journal of Histochemistry
Subjects:
Postoperative cognitive dysfunction
neuroinflammation
circRNAs
TLR4
Online Access:https://ejh.it/index.php/ejh/article/view/3766

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