The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System
Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are res...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.580304/full |
| _version_ | 1818347095602495488 |
|---|---|
| author | Jin Wo Feng Zhang Zhizhong Li Chenghong Sun Wencai Zhang Guodong Sun |
| author_facet | Jin Wo Feng Zhang Zhizhong Li Chenghong Sun Wencai Zhang Guodong Sun |
| author_sort | Jin Wo |
| collection | DOAJ |
| description | Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are responsive to multiple molecular cues and can acquire the capacity to induce various cytokines, such as GM-CSF, IL-4, IL-17, IL-21, IL-22, and IFN-γ. Nevertheless, the exact mechanisms responsible for γδ T cell proinflammatory functions remain poorly understood, particularly in the context of the central nervous system (CNS) diseases. CNS disease, usually leading to irreversible cognitive and physical disability, is becoming a worldwide public health problem. Here, we offer a review of the neuro-inflammatory and immune functions of γδ T cells, intending to understand their roles in CNS diseases, which may be crucial for the development of novel clinical applications. |
| first_indexed | 2024-12-13T17:28:43Z |
| format | Article |
| id | doaj.art-d0e5c2c5544c439da1f7f21aa0e78b85 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T17:28:43Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d0e5c2c5544c439da1f7f21aa0e78b852022-12-21T23:37:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.580304580304The Role of Gamma-Delta T Cells in Diseases of the Central Nervous SystemJin Wo0Feng Zhang1Zhizhong Li2Chenghong Sun3Wencai Zhang4Guodong Sun5Department of Orthopedics, First Affiliated Hospital, Jinan University, Guangzhou, ChinaIntensive Care Unit, First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital, Jinan University, Guangzhou, ChinaState Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, ChinaDepartment of Orthopedics, First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital, Jinan University, Guangzhou, ChinaGamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are responsive to multiple molecular cues and can acquire the capacity to induce various cytokines, such as GM-CSF, IL-4, IL-17, IL-21, IL-22, and IFN-γ. Nevertheless, the exact mechanisms responsible for γδ T cell proinflammatory functions remain poorly understood, particularly in the context of the central nervous system (CNS) diseases. CNS disease, usually leading to irreversible cognitive and physical disability, is becoming a worldwide public health problem. Here, we offer a review of the neuro-inflammatory and immune functions of γδ T cells, intending to understand their roles in CNS diseases, which may be crucial for the development of novel clinical applications.https://www.frontiersin.org/articles/10.3389/fimmu.2020.580304/fullγδ T cellTh17 cellcytokinesinflammationcentral nervous systemIL-17 |
| spellingShingle | Jin Wo Feng Zhang Zhizhong Li Chenghong Sun Wencai Zhang Guodong Sun The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System Frontiers in Immunology γδ T cell Th17 cell cytokines inflammation central nervous system IL-17 |
| title | The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System |
| title_full | The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System |
| title_fullStr | The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System |
| title_full_unstemmed | The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System |
| title_short | The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System |
| title_sort | role of gamma delta t cells in diseases of the central nervous system |
| topic | γδ T cell Th17 cell cytokines inflammation central nervous system IL-17 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.580304/full |
| work_keys_str_mv | AT jinwo theroleofgammadeltatcellsindiseasesofthecentralnervoussystem AT fengzhang theroleofgammadeltatcellsindiseasesofthecentralnervoussystem AT zhizhongli theroleofgammadeltatcellsindiseasesofthecentralnervoussystem AT chenghongsun theroleofgammadeltatcellsindiseasesofthecentralnervoussystem AT wencaizhang theroleofgammadeltatcellsindiseasesofthecentralnervoussystem AT guodongsun theroleofgammadeltatcellsindiseasesofthecentralnervoussystem AT jinwo roleofgammadeltatcellsindiseasesofthecentralnervoussystem AT fengzhang roleofgammadeltatcellsindiseasesofthecentralnervoussystem AT zhizhongli roleofgammadeltatcellsindiseasesofthecentralnervoussystem AT chenghongsun roleofgammadeltatcellsindiseasesofthecentralnervoussystem AT wencaizhang roleofgammadeltatcellsindiseasesofthecentralnervoussystem AT guodongsun roleofgammadeltatcellsindiseasesofthecentralnervoussystem |