Combined Administration of (<i>R</i>)-Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Induces Rapid and Sustained Effects in the CUMS Model of Depression via a TrkB/BDNF-Dependent Mechanism
Ketamine is an effective, rapid-acting antidepressant drug (RAAD), but it induces side effects. To overcome these challenges, attempts have been made to use safer enantiomer ((<i>R</i>)-ketamine) or mGlu2/3 receptor antagonists, which induce ketamine-like effects and enhance its action....
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| 格式: | 文件 |
| 语言: | English |
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MDPI AG
2022-01-01
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| 丛编: | Pharmaceuticals |
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| 在线阅读: | https://www.mdpi.com/1424-8247/15/2/125 |