Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma
Abstract Background Non-Hodgkin’s lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. Unfortunately, DOX is the main cytotoxic drug in R-CHOP and it can l...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00922-4 |
| _version_ | 1811212898834317312 |
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| author | Qiangqiang Zhao Duanfeng Jiang Xiaoying Sun Qiuyu Mo Shaobin Chen Wansong Chen Rong Gui Xianjun Ma |
| author_facet | Qiangqiang Zhao Duanfeng Jiang Xiaoying Sun Qiuyu Mo Shaobin Chen Wansong Chen Rong Gui Xianjun Ma |
| author_sort | Qiangqiang Zhao |
| collection | DOAJ |
| description | Abstract Background Non-Hodgkin’s lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. Unfortunately, DOX is the main cytotoxic drug in R-CHOP and it can lead to adverse reactions. Therefore, it is particularly important to uncover new treatment options for NHL. Results In this study, a novel anti-tumor nanoparticle complex Nm@MSNs-DOX/SM was designed and constructed in this study. Mesoporous silica nanoparticles (MSNs) loaded with Doxorubicin (DOX) and anti-inflammatory drugs Shanzhiside methylester (SM) were used as the core of nanoparticles. Neutrophil membrane (Nm) can be coated with multiple nanonuclei as a shell. DOX combined with SM can enhance the anti-tumor effect, and induce apoptosis of lymphoma cells and inhibit the expression of inflammatory factors related to tumorigenesis depending on the regulation of Bcl-2 family-mediated mitochondrial pathways, such as TNF-α and IL-1β. Consequently, the tumor microenvironment (TME) was reshaped, and the anti-tumor effect of DOX was amplified. Besides, Nm has good biocompatibility and can enhance the EPR effect of Nm@MSNs-DOX/SM and increase the effect of active targeting tumors. Conclusions This suggests that the Nm-modified drug delivery system Nm@MSNs-DOX/SM is a promising targeted chemotherapy and anti-inflammatory therapy nanocomplex, and may be employed as a specific and efficient anti-Lymphoma therapy. |
| first_indexed | 2024-04-12T05:37:05Z |
| format | Article |
| id | doaj.art-d0e86489b75c4504b7a338aaaba26202 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T05:37:05Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-d0e86489b75c4504b7a338aaaba262022022-12-22T03:45:49ZengBMCJournal of Nanobiotechnology1477-31552021-06-0119111910.1186/s12951-021-00922-4Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphomaQiangqiang Zhao0Duanfeng Jiang1Xiaoying Sun2Qiuyu Mo3Shaobin Chen4Wansong Chen5Rong Gui6Xianjun Ma7Department of Blood Transfusion, The Third Xiangya Hospital, Central South UniversityDepartment of Hematology, The Third Xiangya Hospital, Central South UniversityNursing School, Soochow UniversityDepartment of Hematology, Affiliated Hospital of Guilin Medical UniversityDepartment of Hematology, The Qinghai Provincial People’s HospitalCollege of Chemistry and Chemical Engineering, Central South UniversityDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South UniversityDepartment of Blood Transfusion, Qilu Hospital of Shandong UniversityAbstract Background Non-Hodgkin’s lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. Unfortunately, DOX is the main cytotoxic drug in R-CHOP and it can lead to adverse reactions. Therefore, it is particularly important to uncover new treatment options for NHL. Results In this study, a novel anti-tumor nanoparticle complex Nm@MSNs-DOX/SM was designed and constructed in this study. Mesoporous silica nanoparticles (MSNs) loaded with Doxorubicin (DOX) and anti-inflammatory drugs Shanzhiside methylester (SM) were used as the core of nanoparticles. Neutrophil membrane (Nm) can be coated with multiple nanonuclei as a shell. DOX combined with SM can enhance the anti-tumor effect, and induce apoptosis of lymphoma cells and inhibit the expression of inflammatory factors related to tumorigenesis depending on the regulation of Bcl-2 family-mediated mitochondrial pathways, such as TNF-α and IL-1β. Consequently, the tumor microenvironment (TME) was reshaped, and the anti-tumor effect of DOX was amplified. Besides, Nm has good biocompatibility and can enhance the EPR effect of Nm@MSNs-DOX/SM and increase the effect of active targeting tumors. Conclusions This suggests that the Nm-modified drug delivery system Nm@MSNs-DOX/SM is a promising targeted chemotherapy and anti-inflammatory therapy nanocomplex, and may be employed as a specific and efficient anti-Lymphoma therapy.https://doi.org/10.1186/s12951-021-00922-4Neutrophil membraneMesoporous silica nanoparticlesDoxorubicinShanzhiside methylesterLymphoma |
| spellingShingle | Qiangqiang Zhao Duanfeng Jiang Xiaoying Sun Qiuyu Mo Shaobin Chen Wansong Chen Rong Gui Xianjun Ma Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma Journal of Nanobiotechnology Neutrophil membrane Mesoporous silica nanoparticles Doxorubicin Shanzhiside methylester Lymphoma |
| title | Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma |
| title_full | Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma |
| title_fullStr | Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma |
| title_full_unstemmed | Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma |
| title_short | Biomimetic nanotherapy: core–shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma |
| title_sort | biomimetic nanotherapy core shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma |
| topic | Neutrophil membrane Mesoporous silica nanoparticles Doxorubicin Shanzhiside methylester Lymphoma |
| url | https://doi.org/10.1186/s12951-021-00922-4 |
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