High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza
The purpose of the study was to analyze the relationship between the high-sensitivity troponin T levels in patients with confirmed influenza virus infection and its severity determined by mortality during the care process. In addition, a high-sensitivity troponin T cut-off value was sought to allow...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/4/520 |
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| author | Manuel Antonio Tazón-Varela Jon Ortiz de Salido-Menchaca Pedro Muñoz-Cacho Enara Iriondo-Bernabeu María Josefa Martos-Almagro Emma Lavín-López Ander Vega-Zubiaur Edgar José Escalona-Canal Iratxe Alcalde-Díez Carmen Gómez-Vildosola Ainhoa Belzunegui-Gárate Fabiola Espinoza-Cuba José Antonio López-Cejuela Alba García-García Alejandro Torrejón-Cereceda Elena Sabina Nisa-Martínez Diana Moreira Nieto Cintia Hellín-Mercadal Ander García-Caballero Héctor Alonso-Valle |
| author_facet | Manuel Antonio Tazón-Varela Jon Ortiz de Salido-Menchaca Pedro Muñoz-Cacho Enara Iriondo-Bernabeu María Josefa Martos-Almagro Emma Lavín-López Ander Vega-Zubiaur Edgar José Escalona-Canal Iratxe Alcalde-Díez Carmen Gómez-Vildosola Ainhoa Belzunegui-Gárate Fabiola Espinoza-Cuba José Antonio López-Cejuela Alba García-García Alejandro Torrejón-Cereceda Elena Sabina Nisa-Martínez Diana Moreira Nieto Cintia Hellín-Mercadal Ander García-Caballero Héctor Alonso-Valle |
| author_sort | Manuel Antonio Tazón-Varela |
| collection | DOAJ |
| description | The purpose of the study was to analyze the relationship between the high-sensitivity troponin T levels in patients with confirmed influenza virus infection and its severity determined by mortality during the care process. In addition, a high-sensitivity troponin T cut-off value was sought to allow us to a safe discharge from the emergency department. An analytical retrospective observational study was designed in which high-sensitivity troponin T is determined as an exposure factor, patients are followed until the resolution of the clinical picture, and the frequency of mortality is analyzed. We included patients ≥ 16 years old with confirmed influenza virus infection and determination of high-sensitivity troponin T. One hundred twenty-eight patients were included (96.9% survivors, 3.1% deceased). Mean and median blood levels of high-sensitivity troponin T of survivors were 26.2 ± 58.3 ng/L and 14.5 ng/L (IQR 16 ng/L), respectively, and were statistically different when compared with those of the deceased patients, 120.5 ± 170.1 ng/L and 40.5 ng/L (IQR 266.5 ng/L), respectively, <i>p</i> = 0.012. The Youden index using mortality as the reference method was 0.76, and the cut-off value associated with this index was 24 ng/L (sensitivity 100%, specificity 76%, NPV 100%, PPV 4%) with AUC of 88,8% (95% CI: 79.8–92.2%), <i>p</i> < 0.001. We conclude that high-sensitivity troponin T levels in confirmed virus influenza infection are a good predictor of mortality in our population, and this predictor is useful for safely discharging patients from the emergency department. |
| first_indexed | 2024-03-09T10:33:29Z |
| format | Article |
| id | doaj.art-d0e9ad09ddc24e20a9c86d4eeae669ef |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T10:33:29Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-d0e9ad09ddc24e20a9c86d4eeae669ef2023-12-01T21:08:35ZengMDPI AGJournal of Personalized Medicine2075-44262022-03-0112452010.3390/jpm12040520High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed InfluenzaManuel Antonio Tazón-Varela0Jon Ortiz de Salido-Menchaca1Pedro Muñoz-Cacho2Enara Iriondo-Bernabeu3María Josefa Martos-Almagro4Emma Lavín-López5Ander Vega-Zubiaur6Edgar José Escalona-Canal7Iratxe Alcalde-Díez8Carmen Gómez-Vildosola9Ainhoa Belzunegui-Gárate10Fabiola Espinoza-Cuba11José Antonio López-Cejuela12Alba García-García13Alejandro Torrejón-Cereceda14Elena Sabina Nisa-Martínez15Diana Moreira Nieto16Cintia Hellín-Mercadal17Ander García-Caballero18Héctor Alonso-Valle19Servicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainGrupo Salud Comunitaria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainServicio de Urgencias, Hospital de Laredo, 39770 Laredo, SpainGrupo Salud Comunitaria, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, SpainThe purpose of the study was to analyze the relationship between the high-sensitivity troponin T levels in patients with confirmed influenza virus infection and its severity determined by mortality during the care process. In addition, a high-sensitivity troponin T cut-off value was sought to allow us to a safe discharge from the emergency department. An analytical retrospective observational study was designed in which high-sensitivity troponin T is determined as an exposure factor, patients are followed until the resolution of the clinical picture, and the frequency of mortality is analyzed. We included patients ≥ 16 years old with confirmed influenza virus infection and determination of high-sensitivity troponin T. One hundred twenty-eight patients were included (96.9% survivors, 3.1% deceased). Mean and median blood levels of high-sensitivity troponin T of survivors were 26.2 ± 58.3 ng/L and 14.5 ng/L (IQR 16 ng/L), respectively, and were statistically different when compared with those of the deceased patients, 120.5 ± 170.1 ng/L and 40.5 ng/L (IQR 266.5 ng/L), respectively, <i>p</i> = 0.012. The Youden index using mortality as the reference method was 0.76, and the cut-off value associated with this index was 24 ng/L (sensitivity 100%, specificity 76%, NPV 100%, PPV 4%) with AUC of 88,8% (95% CI: 79.8–92.2%), <i>p</i> < 0.001. We conclude that high-sensitivity troponin T levels in confirmed virus influenza infection are a good predictor of mortality in our population, and this predictor is useful for safely discharging patients from the emergency department.https://www.mdpi.com/2075-4426/12/4/520influenzahumantroponinbiomarkersSARS-CoV-2cardiovascular infections |
| spellingShingle | Manuel Antonio Tazón-Varela Jon Ortiz de Salido-Menchaca Pedro Muñoz-Cacho Enara Iriondo-Bernabeu María Josefa Martos-Almagro Emma Lavín-López Ander Vega-Zubiaur Edgar José Escalona-Canal Iratxe Alcalde-Díez Carmen Gómez-Vildosola Ainhoa Belzunegui-Gárate Fabiola Espinoza-Cuba José Antonio López-Cejuela Alba García-García Alejandro Torrejón-Cereceda Elena Sabina Nisa-Martínez Diana Moreira Nieto Cintia Hellín-Mercadal Ander García-Caballero Héctor Alonso-Valle High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza Journal of Personalized Medicine influenza human troponin biomarkers SARS-CoV-2 cardiovascular infections |
| title | High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza |
| title_full | High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza |
| title_fullStr | High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza |
| title_full_unstemmed | High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza |
| title_short | High-Sensitivity Troponin T: A Potential Safety Predictive Biomarker for Discharge from the Emergency Department of Patients with Confirmed Influenza |
| title_sort | high sensitivity troponin t a potential safety predictive biomarker for discharge from the emergency department of patients with confirmed influenza |
| topic | influenza human troponin biomarkers SARS-CoV-2 cardiovascular infections |
| url | https://www.mdpi.com/2075-4426/12/4/520 |
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