Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases
Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.753931/full |
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| author | Yi-Li Zheng Ge Song Jia-Bao Guo Xuan Su Yu-Meng Chen Zheng Yang Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang |
| author_facet | Yi-Li Zheng Ge Song Jia-Bao Guo Xuan Su Yu-Meng Chen Zheng Yang Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang |
| author_sort | Yi-Li Zheng |
| collection | DOAJ |
| description | Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. Research on MSDD pathogenesis, especially on RA and AS, is still in its infancy and major knowledge gaps remain to be filled. The effects of lncRNA/circRNA-miRNA-mRNA axis on MSDD progression help us to fully understand their contribution to the dynamic cellular processes, provide the potential OA, IDD, RA and AS therapeutic strategies. Further studies are needed to explore the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in the pathology of MSDD. |
| first_indexed | 2024-12-18T01:02:28Z |
| format | Article |
| id | doaj.art-d0ebda01c20149d2b82c6592332a3511 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-18T01:02:28Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d0ebda01c20149d2b82c6592332a35112022-12-21T21:26:20ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-10-01910.3389/fcell.2021.753931753931Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative DiseasesYi-Li Zheng0Ge Song1Jia-Bao Guo2Xuan Su3Yu-Meng Chen4Zheng Yang5Pei-Jie Chen6Xue-Qiang Wang7Xue-Qiang Wang8Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaThe Second School of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Shangti Orthopaedic Hospital, Shanghai, ChinaMusculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. Research on MSDD pathogenesis, especially on RA and AS, is still in its infancy and major knowledge gaps remain to be filled. The effects of lncRNA/circRNA-miRNA-mRNA axis on MSDD progression help us to fully understand their contribution to the dynamic cellular processes, provide the potential OA, IDD, RA and AS therapeutic strategies. Further studies are needed to explore the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in the pathology of MSDD.https://www.frontiersin.org/articles/10.3389/fcell.2021.753931/fulldegenerative musculoskeletal disordersagingage-related diseasenon-coding RNAsmiRNAcircRNA |
| spellingShingle | Yi-Li Zheng Ge Song Jia-Bao Guo Xuan Su Yu-Meng Chen Zheng Yang Pei-Jie Chen Xue-Qiang Wang Xue-Qiang Wang Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases Frontiers in Cell and Developmental Biology degenerative musculoskeletal disorders aging age-related disease non-coding RNAs miRNA circRNA |
| title | Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases |
| title_full | Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases |
| title_fullStr | Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases |
| title_full_unstemmed | Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases |
| title_short | Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases |
| title_sort | interactions among lncrna circrna mirna and mrna in musculoskeletal degenerative diseases |
| topic | degenerative musculoskeletal disorders aging age-related disease non-coding RNAs miRNA circRNA |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.753931/full |
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