Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis
Abstract Objectives This review investigates the efficacy and safety of non-invasive brain stimulation (NIBS) combined with psychosocial intervention on depressive symptoms. Materials and methods We systematically searched five electronic databases from their inception to June 2021: PubMed, Embase,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-04-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-03843-0 |
| _version_ | 1817989002454630400 |
|---|---|
| author | Jiali He Yiling Tang Jingxia Lin Guy Faulkner Hector W. H. Tsang Sunny H. W. Chan |
| author_facet | Jiali He Yiling Tang Jingxia Lin Guy Faulkner Hector W. H. Tsang Sunny H. W. Chan |
| author_sort | Jiali He |
| collection | DOAJ |
| description | Abstract Objectives This review investigates the efficacy and safety of non-invasive brain stimulation (NIBS) combined with psychosocial intervention on depressive symptoms. Materials and methods We systematically searched five electronic databases from their inception to June 2021: PubMed, Embase, PsycINFO, Web of Science, and Medline. Randomized or non-randomized clinical trials in which NIBS plus psychosocial intervention was compared to control conditions in people with depressive symptoms were included. Results A total of 17 eligible studies with 660 participants were included. The meta-analysis results showed that NIBS combined with psychosocial therapy had a positive effect on moderate to severe depression ([SMD = − 0.46, 95%CI (− 0.90, − 0.02), I 2 = 73%, p < .01]), but did not significantly improve minimal to mild depression ([SMD = − 0.12, 95%CI (− 0.42, 0.18), I 2 = 0%, p = .63]). Compared with NIBS alone, the combination treatment had a significantly greater effect in alleviating depressive symptoms ([SMD = − 0.84, 95%CI (− 1.25, − 0.42), I 2 = 0%, p = .93]). However, our results suggested that the pooled effect size of ameliorating depression of NIBS plus psychosocial intervention had no significant difference compared with the combination of sham NIBS [SMD = − 0.12, 95%CI (− 0.31, 0.07), I 2 = 0%, p = .60] and psychosocial intervention alone [SMD = − 0.97, 95%CI (− 2.32, 0.38), I 2 = 72%, p = .01]. Conclusion NIBS when combined with psychosocial intervention has a significant positive effect in alleviating moderately to severely depressive symptoms. Further well-designed studies of NIBS combined with psychosocial intervention on depression should be carried out to consolidate the conclusions and explore the in-depth underlying mechanism. |
| first_indexed | 2024-04-14T00:41:49Z |
| format | Article |
| id | doaj.art-d0ec09206e8f47b4a86e1da86368165d |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-14T00:41:49Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-d0ec09206e8f47b4a86e1da86368165d2022-12-22T02:22:10ZengBMCBMC Psychiatry1471-244X2022-04-0122111310.1186/s12888-022-03843-0Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysisJiali He0Yiling Tang1Jingxia Lin2Guy Faulkner3Hector W. H. Tsang4Sunny H. W. Chan5Department of Rehabilitation Sciences, The Hong Kong Polytechnic UniversitySchool of Kinesiology, University of British ColumbiaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic UniversitySchool of Kinesiology, University of British ColumbiaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic UniversitySchool of Health and Social Wellbeing, University of the West of EnglandAbstract Objectives This review investigates the efficacy and safety of non-invasive brain stimulation (NIBS) combined with psychosocial intervention on depressive symptoms. Materials and methods We systematically searched five electronic databases from their inception to June 2021: PubMed, Embase, PsycINFO, Web of Science, and Medline. Randomized or non-randomized clinical trials in which NIBS plus psychosocial intervention was compared to control conditions in people with depressive symptoms were included. Results A total of 17 eligible studies with 660 participants were included. The meta-analysis results showed that NIBS combined with psychosocial therapy had a positive effect on moderate to severe depression ([SMD = − 0.46, 95%CI (− 0.90, − 0.02), I 2 = 73%, p < .01]), but did not significantly improve minimal to mild depression ([SMD = − 0.12, 95%CI (− 0.42, 0.18), I 2 = 0%, p = .63]). Compared with NIBS alone, the combination treatment had a significantly greater effect in alleviating depressive symptoms ([SMD = − 0.84, 95%CI (− 1.25, − 0.42), I 2 = 0%, p = .93]). However, our results suggested that the pooled effect size of ameliorating depression of NIBS plus psychosocial intervention had no significant difference compared with the combination of sham NIBS [SMD = − 0.12, 95%CI (− 0.31, 0.07), I 2 = 0%, p = .60] and psychosocial intervention alone [SMD = − 0.97, 95%CI (− 2.32, 0.38), I 2 = 72%, p = .01]. Conclusion NIBS when combined with psychosocial intervention has a significant positive effect in alleviating moderately to severely depressive symptoms. Further well-designed studies of NIBS combined with psychosocial intervention on depression should be carried out to consolidate the conclusions and explore the in-depth underlying mechanism.https://doi.org/10.1186/s12888-022-03843-0NIBSPsychosocial interventionDepressionSystematic reviewMeta-analysis |
| spellingShingle | Jiali He Yiling Tang Jingxia Lin Guy Faulkner Hector W. H. Tsang Sunny H. W. Chan Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis BMC Psychiatry NIBS Psychosocial intervention Depression Systematic review Meta-analysis |
| title | Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis |
| title_full | Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis |
| title_fullStr | Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis |
| title_full_unstemmed | Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis |
| title_short | Non-invasive brain stimulation combined with psychosocial intervention for depression: a systematic review and meta-analysis |
| title_sort | non invasive brain stimulation combined with psychosocial intervention for depression a systematic review and meta analysis |
| topic | NIBS Psychosocial intervention Depression Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12888-022-03843-0 |
| work_keys_str_mv | AT jialihe noninvasivebrainstimulationcombinedwithpsychosocialinterventionfordepressionasystematicreviewandmetaanalysis AT yilingtang noninvasivebrainstimulationcombinedwithpsychosocialinterventionfordepressionasystematicreviewandmetaanalysis AT jingxialin noninvasivebrainstimulationcombinedwithpsychosocialinterventionfordepressionasystematicreviewandmetaanalysis AT guyfaulkner noninvasivebrainstimulationcombinedwithpsychosocialinterventionfordepressionasystematicreviewandmetaanalysis AT hectorwhtsang noninvasivebrainstimulationcombinedwithpsychosocialinterventionfordepressionasystematicreviewandmetaanalysis AT sunnyhwchan noninvasivebrainstimulationcombinedwithpsychosocialinterventionfordepressionasystematicreviewandmetaanalysis |