Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case report
Abstract Background Tractional retinal detachment with or without secondary tear is a rare complication reported in less than 0.5% of in eyes treated for retinoblastoma. Pars plana vitrectomy (PPV) in eyes with history of retinoblastoma has been associated with a significant risk for recurrence, ext...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-020-1315-7 |
| _version_ | 1818379864607031296 |
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| author | Christina Stathopoulos Jessica Sergenti Marie-Claire Gaillard Francis L. Munier Alejandra Daruich |
| author_facet | Christina Stathopoulos Jessica Sergenti Marie-Claire Gaillard Francis L. Munier Alejandra Daruich |
| author_sort | Christina Stathopoulos |
| collection | DOAJ |
| description | Abstract Background Tractional retinal detachment with or without secondary tear is a rare complication reported in less than 0.5% of in eyes treated for retinoblastoma. Pars plana vitrectomy (PPV) in eyes with history of retinoblastoma has been associated with a significant risk for recurrence, extraocular spread, and systemic metastases. We report here the successful management by PPV under melphalan irrigation of 2 children presenting with tractional retinal detachment after retinoblastoma therapy and scleral buckle surgery. Case presentation A 7-year-old girl with a history of bilateral retinoblastoma (group D) presented with light perception best-corrected visual acuity (BCVA) and tractional retinal detachment (RD) in her left eye, 3 years after the last intra-arterial chemotherapy (IAC) injection. Moreover, she had history of left eye rhegmatogenous RD treated by scleral buckle 1 month after the last IAC and cataract surgery 12 months later. PPV associated with retinectomy, laser photocoagulation and silicone oil tamponade was performed. Silicone oil was removed 4 months later. Fifteen months after PPV, BCVA had increased to 20/32 without recurrence of RD and no evidence of tumor activity. A 7-year-old boy with a history of unilateral retinoblastoma (group D) in his left eye presented with rhegmatogenous RD 21 months after the last treatment for retinoblastoma. Scleral buckle surgery was performed, but 3 weeks later the patient presented with tractional RD associated with proliferative vitreo-retinopathy. BCVA was counting fingers. PPV associated with membrane peel, laser photocoagulation and silicone oil tamponade was performed. Silicone oil was removed after 5 months followed by cataract surgery 5 months later. Twenty months after PPV, BCVA was 20/20 and there was no sign of tumor recurrence. Conclusions PPV under melphalan irrigation, with retinectomy, if necessary, and silicone oil tamponade, allows anatomical and functional improvement in eyes with history of retinoblastoma and scleral buckling developing tractional RD. |
| first_indexed | 2024-12-14T02:09:34Z |
| format | Article |
| id | doaj.art-d0edc1cc2cf741fb9a469d7c7f87b2e6 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-14T02:09:34Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-d0edc1cc2cf741fb9a469d7c7f87b2e62022-12-21T23:20:48ZengBMCBMC Ophthalmology1471-24152020-01-012011510.1186/s12886-020-1315-7Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case reportChristina Stathopoulos0Jessica Sergenti1Marie-Claire Gaillard2Francis L. Munier3Alejandra Daruich4Department of ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des AveuglesDepartment of ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des AveuglesDepartment of ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des AveuglesDepartment of ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des AveuglesDepartment of ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des AveuglesAbstract Background Tractional retinal detachment with or without secondary tear is a rare complication reported in less than 0.5% of in eyes treated for retinoblastoma. Pars plana vitrectomy (PPV) in eyes with history of retinoblastoma has been associated with a significant risk for recurrence, extraocular spread, and systemic metastases. We report here the successful management by PPV under melphalan irrigation of 2 children presenting with tractional retinal detachment after retinoblastoma therapy and scleral buckle surgery. Case presentation A 7-year-old girl with a history of bilateral retinoblastoma (group D) presented with light perception best-corrected visual acuity (BCVA) and tractional retinal detachment (RD) in her left eye, 3 years after the last intra-arterial chemotherapy (IAC) injection. Moreover, she had history of left eye rhegmatogenous RD treated by scleral buckle 1 month after the last IAC and cataract surgery 12 months later. PPV associated with retinectomy, laser photocoagulation and silicone oil tamponade was performed. Silicone oil was removed 4 months later. Fifteen months after PPV, BCVA had increased to 20/32 without recurrence of RD and no evidence of tumor activity. A 7-year-old boy with a history of unilateral retinoblastoma (group D) in his left eye presented with rhegmatogenous RD 21 months after the last treatment for retinoblastoma. Scleral buckle surgery was performed, but 3 weeks later the patient presented with tractional RD associated with proliferative vitreo-retinopathy. BCVA was counting fingers. PPV associated with membrane peel, laser photocoagulation and silicone oil tamponade was performed. Silicone oil was removed after 5 months followed by cataract surgery 5 months later. Twenty months after PPV, BCVA was 20/20 and there was no sign of tumor recurrence. Conclusions PPV under melphalan irrigation, with retinectomy, if necessary, and silicone oil tamponade, allows anatomical and functional improvement in eyes with history of retinoblastoma and scleral buckling developing tractional RD.https://doi.org/10.1186/s12886-020-1315-7RetinoblastomaPars plana vitrectomytractional retinal detachmentmelphalan irrigation |
| spellingShingle | Christina Stathopoulos Jessica Sergenti Marie-Claire Gaillard Francis L. Munier Alejandra Daruich Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case report BMC Ophthalmology Retinoblastoma Pars plana vitrectomy tractional retinal detachment melphalan irrigation |
| title | Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case report |
| title_full | Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case report |
| title_fullStr | Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case report |
| title_full_unstemmed | Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case report |
| title_short | Pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma: a case report |
| title_sort | pars plana vitrectomy under melphalan irrigation for recurrent retinal detachment in eyes treated for retinoblastoma a case report |
| topic | Retinoblastoma Pars plana vitrectomy tractional retinal detachment melphalan irrigation |
| url | https://doi.org/10.1186/s12886-020-1315-7 |
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