Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease
Levodopa, a dopamine prodrug, alleviates the motor symptoms of Parkinson’s disease (PD), but its chronic use gives rise to levodopa-induced dyskinesia (LID). However, it remains unclear whether levodopa pharmacodynamics is altered during the progressive onset of LID. Using in vivo fast-scan cyclic v...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1335474/full |
| _version_ | 1797347912710094848 |
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| author | Jeongrak Park Seongtak Kang Yaebin Lee Ji-Woong Choi Yong-Seok Oh |
| author_facet | Jeongrak Park Seongtak Kang Yaebin Lee Ji-Woong Choi Yong-Seok Oh |
| author_sort | Jeongrak Park |
| collection | DOAJ |
| description | Levodopa, a dopamine prodrug, alleviates the motor symptoms of Parkinson’s disease (PD), but its chronic use gives rise to levodopa-induced dyskinesia (LID). However, it remains unclear whether levodopa pharmacodynamics is altered during the progressive onset of LID. Using in vivo fast-scan cyclic voltammetry and second-derivative-based background drift removal, we continuously measured tonic dopamine levels using high temporal resolution recording over 1-h. Increases to tonic dopamine levels following acute levodopa administration were slow and marginal within the naïve PD model. However, these levels increased faster and higher in the LID model. Furthermore, we identified a strong positive correlation of dyskinetic behavior with the rate of dopamine increase, but much less with its cumulative level, at each time point. Here, we identified the altered signature of striatal DA dynamics underlying LID in PD using an advanced FSCV technique that demonstrates the long-range dynamics of tonic dopamine following drug administration. |
| first_indexed | 2024-03-08T11:55:47Z |
| format | Article |
| id | doaj.art-d0ee2d4fe37d4abe9d0a7dfa77244278 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T11:55:47Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d0ee2d4fe37d4abe9d0a7dfa772442782024-01-24T04:43:52ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011210.3389/fbioe.2024.13354741335474Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s diseaseJeongrak Park0Seongtak Kang1Yaebin Lee2Ji-Woong Choi3Yong-Seok Oh4Department of Brain Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of KoreaDepartment of Electrical Engineering and Computer Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaDepartment of Electrical Engineering and Computer Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaDepartment of Electrical Engineering and Computer Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaDepartment of Brain Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of KoreaLevodopa, a dopamine prodrug, alleviates the motor symptoms of Parkinson’s disease (PD), but its chronic use gives rise to levodopa-induced dyskinesia (LID). However, it remains unclear whether levodopa pharmacodynamics is altered during the progressive onset of LID. Using in vivo fast-scan cyclic voltammetry and second-derivative-based background drift removal, we continuously measured tonic dopamine levels using high temporal resolution recording over 1-h. Increases to tonic dopamine levels following acute levodopa administration were slow and marginal within the naïve PD model. However, these levels increased faster and higher in the LID model. Furthermore, we identified a strong positive correlation of dyskinetic behavior with the rate of dopamine increase, but much less with its cumulative level, at each time point. Here, we identified the altered signature of striatal DA dynamics underlying LID in PD using an advanced FSCV technique that demonstrates the long-range dynamics of tonic dopamine following drug administration.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1335474/fullParkinson’s diseaselevodopa-induced dyskinesiadopaminefast-scan cyclic voltammetrylevodopa pharmacodynamics |
| spellingShingle | Jeongrak Park Seongtak Kang Yaebin Lee Ji-Woong Choi Yong-Seok Oh Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease Frontiers in Bioengineering and Biotechnology Parkinson’s disease levodopa-induced dyskinesia dopamine fast-scan cyclic voltammetry levodopa pharmacodynamics |
| title | Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease |
| title_full | Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease |
| title_fullStr | Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease |
| title_full_unstemmed | Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease |
| title_short | Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease |
| title_sort | continuous long range measurement of tonic dopamine with advanced fscv for pharmacodynamic analysis of levodopa induced dyskinesia in parkinson s disease |
| topic | Parkinson’s disease levodopa-induced dyskinesia dopamine fast-scan cyclic voltammetry levodopa pharmacodynamics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1335474/full |
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