Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease

Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease

Levodopa, a dopamine prodrug, alleviates the motor symptoms of Parkinson’s disease (PD), but its chronic use gives rise to levodopa-induced dyskinesia (LID). However, it remains unclear whether levodopa pharmacodynamics is altered during the progressive onset of LID. Using in vivo fast-scan cyclic v...

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Bibliographic Details
Main Authors: Jeongrak Park, Seongtak Kang, Yaebin Lee, Ji-Woong Choi, Yong-Seok Oh
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Parkinson’s disease
levodopa-induced dyskinesia
dopamine
fast-scan cyclic voltammetry
levodopa pharmacodynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1335474/full

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