Periostin - A Novel Systemic Biomarker for Eosinophilic Airway Inflammation: A Case Control Study
Introduction: Chronic airway inflammation and remodelling are fundamental features of asthma. The molecular phenotypes in asthma are Th2 high and Th2 low. Serum periostin is a biomarker which aid in understanding Th2 high eosinophilic asthma. Aim: The present study aimed to identify whether or n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7166/14553_CE[Ra1]_F(GH)_PF1(Ek_Om)_PFA(P)_PF2(PAG).pdf |
| Summary: | Introduction: Chronic airway inflammation and remodelling are
fundamental features of asthma. The molecular phenotypes in
asthma are Th2 high and Th2 low. Serum periostin is a biomarker
which aid in understanding Th2 high eosinophilic asthma.
Aim: The present study aimed to identify whether or not serum
periostin is a systemic biomarker for eosinophilic airway
inflammation in asthmatics.
Materials and Methods: The study was designed as a
prospective, case control study. Patients who presented with
consistent symptoms of asthma and confirmed by spirometry
with reversibility were the cases. The controls were healthy
subjects who had no history of lung disease with normal lung
function. The sputum and blood samples were collected from
both the groups. Sputum eosinophils, Absolute Eosinophil
Counts (AEC) and serum periostin levels were compared
between the groups.
Results: The study comprised of 101 participants in which 30
were controls and 71 were cases. In the study group, mean post
FEV1 was 64.45. There was a positive correlation of sputum
eosinophils with severity of obstruction. The ROC curve analysis
showed the cut-off value of 24.556 for serum periostin with the
p-value of <0.001. As the severity of obstruction increased, the
serum periostin levels were also found to be increased. Serum
periostin had a sensitivity and specificity of 97.18% and 86.67%
with a diagnostic accuracy of 94.06%.
Conclusion: Serum periostin appears to be a more sensitive
tool for detection of airflow limitation in asthmatic patients with
a Th2 high eosinophilic phenotype when compared to AEC and
sputum eosinophils. |
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| ISSN: | 2249-782X 0973-709X |