Inversed Ratio of CD39/CD73 Expression on γδ T Cells in HIV Versus Healthy Controls Correlates With Immune Activation and Disease Progression

Inversed Ratio of CD39/CD73 Expression on γδ T Cells in HIV Versus Healthy Controls Correlates With Immune Activation and Disease Progression

Backgroundγδ T cells are unconventional T cells that have been demonstrated to be crucial for the pathogenesis and potentially for the cure of HIV-1 infection. The ectonucleotidase CD39 is part of the purinergic pathway that regulates immune responses by degradation of pro-inflammatory ATP in concer...

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Bibliographic Details
Main Authors: Katharina Kolbe, Melanie Wittner, Philip Hartjen, Anja-Dorothee Hüfner, Olaf Degen, Christin Ackermann, Leon Cords, Hans-Jürgen Stellbrink, Friedrich Haag, Julian Schulze zur Wiesch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
γδ T cells
HIV-1
T cell
CD39
CD73
Vδ2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.867167/full

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