Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest

Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest

Abstract Background Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in the current knowledge, we test the hypothesis that MTx can improve outcom...

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Bibliographic Details
Main Authors: Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C. Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J. Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang, Lance B. Becker
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Medicine
Subjects:
Mitochondrial transplantation
Cardiac arrest
Ischemia and reperfusion
Mitochondria
Online Access:https://doi.org/10.1186/s12916-023-02759-0

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