Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis
Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin enzyme inhibitor (ACEI)...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2022-07-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/825 |
| _version_ | 1797223957054619648 |
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| author | Assim Oday Farooq Nadia Hameed Mohammed |
| author_facet | Assim Oday Farooq Nadia Hameed Mohammed |
| author_sort | Assim Oday Farooq |
| collection | DOAJ |
| description |
Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin
enzyme inhibitor (ACEI) that is widely used to control elevation in the blood pressure. This drug has anti-inflammatory activities, for this reason we try to investigate its action in RA. In this study we found that captopril decreases both expression and intensity of TLR2.
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| first_indexed | 2024-04-24T13:45:28Z |
| format | Article |
| id | doaj.art-d0f0df7b35384fbb9e5c357ff4480f38 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:28Z |
| publishDate | 2022-07-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-d0f0df7b35384fbb9e5c357ff4480f382024-04-04T06:56:26ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2022-07-0122110.32947/ajps.v22i1.825Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced ArthritisAssim Oday Farooq0Nadia Hameed Mohammed1Ministry of Health, Baghdad, IraqCollage of Pharmacy/ Mustansiriyah University, Baghdad, Iraq Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin enzyme inhibitor (ACEI) that is widely used to control elevation in the blood pressure. This drug has anti-inflammatory activities, for this reason we try to investigate its action in RA. In this study we found that captopril decreases both expression and intensity of TLR2. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/825Rheumatoid arthritis, Captopril, Toll like receptor |
| spellingShingle | Assim Oday Farooq Nadia Hameed Mohammed Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis Al-Mustansiriyah Journal of Pharmaceutical Sciences Rheumatoid arthritis, Captopril, Toll like receptor |
| title | Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis |
| title_full | Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis |
| title_fullStr | Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis |
| title_full_unstemmed | Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis |
| title_short | Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis |
| title_sort | effect of captopril on toll like receptor expression in adjuvant induced arthritis |
| topic | Rheumatoid arthritis, Captopril, Toll like receptor |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/825 |
| work_keys_str_mv | AT assimodayfarooq effectofcaptoprilontolllikereceptorexpressioninadjuvantinducedarthritis AT nadiahameedmohammed effectofcaptoprilontolllikereceptorexpressioninadjuvantinducedarthritis |