Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung
PURPOSE The purpose of this study was to investigate the effects of hyperventilation in the presence of fine particulate matter (PM2.5) on inflammatory and apoptotic responses in the lungs of mice during a single bout of aerobic exercise. METHODS The FVB/N mice were housed in a controlled SPF room a...
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| Format: | Article |
| Language: | Korean |
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The Korean Society of Exercise Physiology
2023-11-01
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| Series: | 운동과학 |
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| Online Access: | http://ksep-es.org/upload/pdf/ksep-2023-00437.pdf |
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| author | 동진 염 i Zhang Ziy 진한 박 준호 장 병훈 소 강규 이 청훈 강 |
| author_facet | 동진 염 i Zhang Ziy 진한 박 준호 장 병훈 소 강규 이 청훈 강 |
| author_sort | 동진 염 |
| collection | DOAJ |
| description | PURPOSE The purpose of this study was to investigate the effects of hyperventilation in the presence of fine particulate matter (PM2.5) on inflammatory and apoptotic responses in the lungs of mice during a single bout of aerobic exercise. METHODS The FVB/N mice were housed in a controlled SPF room and randomly divided into four groups: control (CON, n=7), fine particulate matter exposure (PM, n=7), PM and exercise (PME, n=7), and exercise only (EX, n=7). Acute PM exposure and/or aerobic treadmill exercise were undertaken according to the groups using a specially designed PM treadmill chamber. RESULTS Protein expression and phosphorylation of p65 NF-kB in mouse lungs were significantly increased by acute exercise, but not by PM exposure. Basal protein levels and phosphorylation of MAPKs (p38, ERK, and JNK) were significantly increased in the PME group, but were lower in the PM and EX groups. Although the percentage of collagen fibers in lung tissue was not affected by PM exposure, the expression of pro- and antiapoptotic factors BAX, BID, and Bcl-2 was significantly elevated by inhalation of PM during exercise. CONCLUSIONS In this study, the MAPKs family was activated by excessive PM inhalation during exercise and similar changes in apoptosis-related signaling were observed. This suggests that even a single bout of inhalation of fine particulate matter during exercise can affect factors associated with inflammation and cell death. |
| first_indexed | 2024-03-08T00:51:23Z |
| format | Article |
| id | doaj.art-d0f11f3292a54252acfb0a14cd492ecc |
| institution | Directory Open Access Journal |
| issn | 1226-1726 2384-0544 |
| language | Korean |
| last_indexed | 2024-03-08T00:51:23Z |
| publishDate | 2023-11-01 |
| publisher | The Korean Society of Exercise Physiology |
| record_format | Article |
| series | 운동과학 |
| spelling | doaj.art-d0f11f3292a54252acfb0a14cd492ecc2024-02-15T04:05:52ZkorThe Korean Society of Exercise Physiology운동과학1226-17262384-05442023-11-0110.15857/ksep.2023.004371056Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung동진 염0i Zhang Ziy1진한 박2준호 장3병훈 소4강규 이5청훈 강6Department of Health and Exercise Science, Inha University, Incheon, KoreaTianjin Key Laboratory of Exercise Physiology and Sports Medicine, Institute of sport, Exercise & Health, Tianjin University of Sports, Tianjin, ChinaDepartment of Health and Exercise Science, Inha University, Incheon, KoreaDepartment of Health and Exercise Science, Inha University, Incheon, KoreaDepartment of Health and Exercise Science, Inha University, Incheon, KoreaDepartment of Health and Exercise Science, Inha University, Incheon, KoreaDepartment of Health and Exercise Science, Inha University, Incheon, KoreaPURPOSE The purpose of this study was to investigate the effects of hyperventilation in the presence of fine particulate matter (PM2.5) on inflammatory and apoptotic responses in the lungs of mice during a single bout of aerobic exercise. METHODS The FVB/N mice were housed in a controlled SPF room and randomly divided into four groups: control (CON, n=7), fine particulate matter exposure (PM, n=7), PM and exercise (PME, n=7), and exercise only (EX, n=7). Acute PM exposure and/or aerobic treadmill exercise were undertaken according to the groups using a specially designed PM treadmill chamber. RESULTS Protein expression and phosphorylation of p65 NF-kB in mouse lungs were significantly increased by acute exercise, but not by PM exposure. Basal protein levels and phosphorylation of MAPKs (p38, ERK, and JNK) were significantly increased in the PME group, but were lower in the PM and EX groups. Although the percentage of collagen fibers in lung tissue was not affected by PM exposure, the expression of pro- and antiapoptotic factors BAX, BID, and Bcl-2 was significantly elevated by inhalation of PM during exercise. CONCLUSIONS In this study, the MAPKs family was activated by excessive PM inhalation during exercise and similar changes in apoptosis-related signaling were observed. This suggests that even a single bout of inhalation of fine particulate matter during exercise can affect factors associated with inflammation and cell death.http://ksep-es.org/upload/pdf/ksep-2023-00437.pdfparticulate matterlung inflammationtreadmill exercisemouselung tissue |
| spellingShingle | 동진 염 i Zhang Ziy 진한 박 준호 장 병훈 소 강규 이 청훈 강 Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung 운동과학 particulate matter lung inflammation treadmill exercise mouse lung tissue |
| title | Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung |
| title_full | Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung |
| title_fullStr | Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung |
| title_full_unstemmed | Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung |
| title_short | Effects of Hyperventilation of Fine Particulate Matter (PM2.5) During a Single Exercise Bout on Inflammatory and Apoptotic Responses in the Mouse Lung |
| title_sort | effects of hyperventilation of fine particulate matter pm2 5 during a single exercise bout on inflammatory and apoptotic responses in the mouse lung |
| topic | particulate matter lung inflammation treadmill exercise mouse lung tissue |
| url | http://ksep-es.org/upload/pdf/ksep-2023-00437.pdf |
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