Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations
Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical alkylation procedure to several quinazolinedion...
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/14/5/1860/ |
| _version_ | 1818387546270334976 |
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| author | Martha Cecilia Meza Jesús Ramón Rodríguez Karla Alejandra Espinoza Ignacio Alfredo Rivero Leticia Guerrero |
| author_facet | Martha Cecilia Meza Jesús Ramón Rodríguez Karla Alejandra Espinoza Ignacio Alfredo Rivero Leticia Guerrero |
| author_sort | Martha Cecilia Meza |
| collection | DOAJ |
| description | Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations. |
| first_indexed | 2024-12-14T04:11:40Z |
| format | Article |
| id | doaj.art-d0f1d1e611f547e2bac08be0a3dfe378 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T04:11:40Z |
| publishDate | 2009-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d0f1d1e611f547e2bac08be0a3dfe3782022-12-21T23:17:38ZengMDPI AGMolecules1420-30492009-05-011451860186810.3390/molecules14051860Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave IrradiationsMartha Cecilia MezaJesús Ramón RodríguezKarla Alejandra EspinozaIgnacio Alfredo RiveroLeticia GuerreroAlkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties.We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1-methyl-3-(2'-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2'-(4'-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations.http://www.mdpi.com/1420-3049/14/5/1860/alkylationquinazoline-24-dioneantihypertensive activitymicrowaves |
| spellingShingle | Martha Cecilia Meza Jesús Ramón Rodríguez Karla Alejandra Espinoza Ignacio Alfredo Rivero Leticia Guerrero Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations Molecules alkylation quinazoline-2 4-dione antihypertensive activity microwaves |
| title | Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations |
| title_full | Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations |
| title_fullStr | Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations |
| title_full_unstemmed | Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations |
| title_short | Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations |
| title_sort | alkylation of 2 4 1h 3h quinazolinediones with dialkyl carbonates under microwave irradiations |
| topic | alkylation quinazoline-2 4-dione antihypertensive activity microwaves |
| url | http://www.mdpi.com/1420-3049/14/5/1860/ |
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