Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

The Polycomb repressive complex 2 (PRC2) is a multicomponent histone H3K27 methyltransferase complex, best known for silencing the Hox genes during embryonic development. The Polycomb-like proteins PHF1, MTF2, and PHF19 are critical components of PRC2 by stimulating its catalytic activity in embryon...

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Bibliographic Details
Main Authors: Cheng Dong, Reiko Nakagawa, Kyohei Oyama, Yusuke Yamamoto, Weilian Zhang, Aiping Dong, Yanjun Li, Yuriko Yoshimura, Hiroyuki Kamiya, Jun-ichi Nakayama, Jun Ueda, Jinrong Min
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
epigenetics
PHF1
Tudor
Polycomb
histone methylation
chromatin
Online Access:https://elifesciences.org/articles/58675

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