Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide and the disease outcome commonly depends upon the tumour stage at the time of diagnosis. However, this cancer can often be asymptomatic during the early stages and remain undetected until the later stages of tumour d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/18/12/2588 |
| _version_ | 1798044878142177280 |
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| author | Andrew Smith Isabella Piga Manuel Galli Martina Stella Vanna Denti Marina Del Puppo Fulvio Magni |
| author_facet | Andrew Smith Isabella Piga Manuel Galli Martina Stella Vanna Denti Marina Del Puppo Fulvio Magni |
| author_sort | Andrew Smith |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide and the disease outcome commonly depends upon the tumour stage at the time of diagnosis. However, this cancer can often be asymptomatic during the early stages and remain undetected until the later stages of tumour development, having a significant impact on patient prognosis. However, our comprehension of the mechanisms underlying the development of gastric malignancies is still lacking. For these reasons, the search for new diagnostic and prognostic markers for gastric cancer is an ongoing pursuit. Modern mass spectrometry imaging (MSI) techniques, in particular matrix-assisted laser desorption/ionisation (MALDI), have emerged as a plausible tool in clinical pathology as a whole. More specifically, MALDI-MSI is being increasingly employed in the study of gastric cancer and has already elucidated some important disease checkpoints that may help us to better understand the molecular mechanisms underpinning this aggressive cancer. Here we report the state of the art of MALDI-MSI approaches, ranging from sample preparation to statistical analysis, and provide a complete review of the key findings that have been reported in the literature thus far. |
| first_indexed | 2024-04-11T23:11:21Z |
| format | Article |
| id | doaj.art-d0fb8f16e023474aaa1dcb956058ecbb |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-11T23:11:21Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d0fb8f16e023474aaa1dcb956058ecbb2022-12-22T03:57:49ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-12-011812258810.3390/ijms18122588ijms18122588Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini ReviewAndrew Smith0Isabella Piga1Manuel Galli2Martina Stella3Vanna Denti4Marina Del Puppo5Fulvio Magni6Department of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, 20854 Vedano al Lambro, ItalyDepartment of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, 20854 Vedano al Lambro, ItalyDepartment of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, 20854 Vedano al Lambro, ItalyDepartment of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, 20854 Vedano al Lambro, ItalyDepartment of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, 20854 Vedano al Lambro, ItalyDepartment of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, 20854 Vedano al Lambro, ItalyDepartment of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, 20854 Vedano al Lambro, ItalyGastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide and the disease outcome commonly depends upon the tumour stage at the time of diagnosis. However, this cancer can often be asymptomatic during the early stages and remain undetected until the later stages of tumour development, having a significant impact on patient prognosis. However, our comprehension of the mechanisms underlying the development of gastric malignancies is still lacking. For these reasons, the search for new diagnostic and prognostic markers for gastric cancer is an ongoing pursuit. Modern mass spectrometry imaging (MSI) techniques, in particular matrix-assisted laser desorption/ionisation (MALDI), have emerged as a plausible tool in clinical pathology as a whole. More specifically, MALDI-MSI is being increasingly employed in the study of gastric cancer and has already elucidated some important disease checkpoints that may help us to better understand the molecular mechanisms underpinning this aggressive cancer. Here we report the state of the art of MALDI-MSI approaches, ranging from sample preparation to statistical analysis, and provide a complete review of the key findings that have been reported in the literature thus far.https://www.mdpi.com/1422-0067/18/12/2588gastric cancerMALDI imagingproteomicsmetabolomicslipidomics |
| spellingShingle | Andrew Smith Isabella Piga Manuel Galli Martina Stella Vanna Denti Marina Del Puppo Fulvio Magni Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review International Journal of Molecular Sciences gastric cancer MALDI imaging proteomics metabolomics lipidomics |
| title | Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review |
| title_full | Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review |
| title_fullStr | Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review |
| title_full_unstemmed | Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review |
| title_short | Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging in the Study of Gastric Cancer: A Mini Review |
| title_sort | matrix assisted laser desorption ionisation mass spectrometry imaging in the study of gastric cancer a mini review |
| topic | gastric cancer MALDI imaging proteomics metabolomics lipidomics |
| url | https://www.mdpi.com/1422-0067/18/12/2588 |
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