Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients
Abstract Background Schizophrenia (SCZ) is a heritable, refractory, and devastating psychiatric disorder. Previous studies have shown that the variants of CUB and sushi multiple domains 1 (CSMD1) demonstrate significant genome-wide association with SCZ. However, few studies have been conducted on th...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12888-019-2089-4 |
| _version_ | 1818041180434202624 |
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| author | Yansong Liu Xiaoqian Fu Zhen Tang Cui Li Yong Xu Fuquan Zhang Deyi Zhou Chunming Zhu |
| author_facet | Yansong Liu Xiaoqian Fu Zhen Tang Cui Li Yong Xu Fuquan Zhang Deyi Zhou Chunming Zhu |
| author_sort | Yansong Liu |
| collection | DOAJ |
| description | Abstract Background Schizophrenia (SCZ) is a heritable, refractory, and devastating psychiatric disorder. Previous studies have shown that the variants of CUB and sushi multiple domains 1 (CSMD1) demonstrate significant genome-wide association with SCZ. However, few studies have been conducted on the effect of antipsychotics on the expression levels of CSMD1. This study explored whether a change occurs in the expression of the CSMD1 gene before and after antipsychotic treatment in SCZ patients. Methods The study population comprised Han Chinese patients from eastern China, including 32 SCZ patients and 48 healthy controls. The expression of CSMD1 before and after treatment in the SCZ group and between the two groups was analyzed using real-time quantitative polymerase chain reaction (RT-qPCR). Results The expression levels of the CSMD1 gene in the peripheral blood mononuclear cells (PBMCs) of SCZ patients were lower than those in the healthy controls. The expression levels of the CSMD1 gene in the PBMCs of the SCZ patients after antipsychotic treatment were higher than those in the baseline SCZ patients (all P < 0.05). Conclusions Our results showed that the expression levels of CSMD1 are correlated with the development and treatment of SCZ, providing further evidence for the involvement of CSMD1 in SCZ. |
| first_indexed | 2024-12-10T08:26:19Z |
| format | Article |
| id | doaj.art-d0fbac29977f47a1b96a4ffa9676fbe7 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-10T08:26:19Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-d0fbac29977f47a1b96a4ffa9676fbe72022-12-22T01:56:14ZengBMCBMC Psychiatry1471-244X2019-04-011911510.1186/s12888-019-2089-4Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patientsYansong Liu0Xiaoqian Fu1Zhen Tang2Cui Li3Yong Xu4Fuquan Zhang5Deyi Zhou6Chunming Zhu7Department of Clinical Psychology, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversityDepartment of Clinical Psychology, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversityDepartment of Clinical Psychology, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversityDepartment of Psychology, Xinghua People’s HospitalDepartment of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical UniversityDepartment of Clinical Psychology, Wuxi Mental Health Center, Nanjing Medical UniversityDepartment of Clinical Psychology, Wuxi Mental Health Center, Nanjing Medical UniversityDepartment of Clinical Psychology, Wuxi Mental Health Center, Nanjing Medical UniversityAbstract Background Schizophrenia (SCZ) is a heritable, refractory, and devastating psychiatric disorder. Previous studies have shown that the variants of CUB and sushi multiple domains 1 (CSMD1) demonstrate significant genome-wide association with SCZ. However, few studies have been conducted on the effect of antipsychotics on the expression levels of CSMD1. This study explored whether a change occurs in the expression of the CSMD1 gene before and after antipsychotic treatment in SCZ patients. Methods The study population comprised Han Chinese patients from eastern China, including 32 SCZ patients and 48 healthy controls. The expression of CSMD1 before and after treatment in the SCZ group and between the two groups was analyzed using real-time quantitative polymerase chain reaction (RT-qPCR). Results The expression levels of the CSMD1 gene in the peripheral blood mononuclear cells (PBMCs) of SCZ patients were lower than those in the healthy controls. The expression levels of the CSMD1 gene in the PBMCs of the SCZ patients after antipsychotic treatment were higher than those in the baseline SCZ patients (all P < 0.05). Conclusions Our results showed that the expression levels of CSMD1 are correlated with the development and treatment of SCZ, providing further evidence for the involvement of CSMD1 in SCZ.http://link.springer.com/article/10.1186/s12888-019-2089-4SchizophreniaCSMD1Antipsychotics |
| spellingShingle | Yansong Liu Xiaoqian Fu Zhen Tang Cui Li Yong Xu Fuquan Zhang Deyi Zhou Chunming Zhu Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients BMC Psychiatry Schizophrenia CSMD1 Antipsychotics |
| title | Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients |
| title_full | Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients |
| title_fullStr | Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients |
| title_full_unstemmed | Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients |
| title_short | Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients |
| title_sort | altered expression of the csmd1 gene in the peripheral blood of schizophrenia patients |
| topic | Schizophrenia CSMD1 Antipsychotics |
| url | http://link.springer.com/article/10.1186/s12888-019-2089-4 |
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