Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone?
BackgroundParoxysmal kinesigenic dyskinesia (PKD) is characterized by recurrent episodes of movement-induced motor attacks. PKD patients may have concomitant epilepsy. Differentiation between the two disorders and effective control of both diseases remain challenging.Case PresentationWe present a Ch...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.826897/full |
| _version_ | 1798017745167581184 |
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| author | Jun-Hong Geng Yang Zheng Quan-Fu Li Qun Hou Xiao-Hang Wang Yan Jiang |
| author_facet | Jun-Hong Geng Yang Zheng Quan-Fu Li Qun Hou Xiao-Hang Wang Yan Jiang |
| author_sort | Jun-Hong Geng |
| collection | DOAJ |
| description | BackgroundParoxysmal kinesigenic dyskinesia (PKD) is characterized by recurrent episodes of movement-induced motor attacks. PKD patients may have concomitant epilepsy. Differentiation between the two disorders and effective control of both diseases remain challenging.Case PresentationWe present a Chinese girl with typical manifestations of PKD, who also suffered from generalized tonic-clonic seizure attacks at the same time. Genetic testing confirmed a PRRT2 mutation (c.649dupC). Oxcarbazepine was initially used, but withdrawn due to a hypersensitivity reaction. Levetiracetam was initiated afterwards, which was effective for seizures but failed to control her PKD symptoms. The addition of lacosamide (LCM) completely controlled her PKD symptoms.ConclusionThis is the first case reporting the effectiveness of LCM for concomitant PKD and epilepsy. Our case proposes a novel alternative for such patients who are resistant or cannot tolerate conventional anti-sodium antiepileptics. |
| first_indexed | 2024-04-11T16:12:18Z |
| format | Article |
| id | doaj.art-d0fe645937c04ecfaf83fde0596a0f7f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T16:12:18Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d0fe645937c04ecfaf83fde0596a0f7f2022-12-22T04:14:39ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-02-011310.3389/fneur.2022.826897826897Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone?Jun-Hong GengYang ZhengQuan-Fu LiQun HouXiao-Hang WangYan JiangBackgroundParoxysmal kinesigenic dyskinesia (PKD) is characterized by recurrent episodes of movement-induced motor attacks. PKD patients may have concomitant epilepsy. Differentiation between the two disorders and effective control of both diseases remain challenging.Case PresentationWe present a Chinese girl with typical manifestations of PKD, who also suffered from generalized tonic-clonic seizure attacks at the same time. Genetic testing confirmed a PRRT2 mutation (c.649dupC). Oxcarbazepine was initially used, but withdrawn due to a hypersensitivity reaction. Levetiracetam was initiated afterwards, which was effective for seizures but failed to control her PKD symptoms. The addition of lacosamide (LCM) completely controlled her PKD symptoms.ConclusionThis is the first case reporting the effectiveness of LCM for concomitant PKD and epilepsy. Our case proposes a novel alternative for such patients who are resistant or cannot tolerate conventional anti-sodium antiepileptics.https://www.frontiersin.org/articles/10.3389/fneur.2022.826897/fulllacosamideparoxysmal kinesigenic dyskinesiaepilepsymovement disorderPRRT2 |
| spellingShingle | Jun-Hong Geng Yang Zheng Quan-Fu Li Qun Hou Xiao-Hang Wang Yan Jiang Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone? Frontiers in Neurology lacosamide paroxysmal kinesigenic dyskinesia epilepsy movement disorder PRRT2 |
| title | Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone? |
| title_full | Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone? |
| title_fullStr | Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone? |
| title_full_unstemmed | Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone? |
| title_short | Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone? |
| title_sort | case report a case of concomitant paroxysmal kinesigenic dyskinesia and epilepsy can we treat two birds with one stone |
| topic | lacosamide paroxysmal kinesigenic dyskinesia epilepsy movement disorder PRRT2 |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.826897/full |
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