STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death

STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death

Glioblastoma (GBM) is a devastating disease and the most common primary brain malignancy of adults with a median survival barely exceeding one year. Recent findings suggest that the antipsychotic drug pimozide triggers an autophagy-dependent, lysosomal type of cell death in GBM cells with possible i...

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Bibliographic Details
Main Authors: Janina Remy, Benedikt Linder, Ulrike Weirauch, Bryan W. Day, Brett W. Stringer, Christel Herold-Mende, Achim Aigner, Knut Krohn, Donat Kögel
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
STAT3
glioblastoma
pimozide
autophagy
autophagy-dependent cell death
lysosome
Online Access:https://www.mdpi.com/2072-6694/14/2/339

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