Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes
Abstract Background Systemic inflammatory processes plausibly contribute to the development of cardiovascular complications, causing increased morbidity and mortality in type 2 diabetes. Circulating inflammatory markers, i.e., interleukin (IL)-6 and tumour necrosis factor-α, are associated with neur...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-01-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-021-01437-w |
| _version_ | 1819229347001663488 |
|---|---|
| author | A. M. Wegeberg T. Okdahl S. Riahi N. Ejskjaer F. Pociot J. Størling B. Brock C. Brock |
| author_facet | A. M. Wegeberg T. Okdahl S. Riahi N. Ejskjaer F. Pociot J. Størling B. Brock C. Brock |
| author_sort | A. M. Wegeberg |
| collection | DOAJ |
| description | Abstract Background Systemic inflammatory processes plausibly contribute to the development of cardiovascular complications, causing increased morbidity and mortality in type 2 diabetes. Circulating inflammatory markers, i.e., interleukin (IL)-6 and tumour necrosis factor-α, are associated with neurocardiac measures. We examined a broad panel of various inflammatory and inflammation-related serum markers to obtain more detailed insight into the possible neuro-immune interaction between cardiovascular regulation and systemic level of inflammation. Methods Serum samples from 100 participants with type 2 diabetes were analysed. Heart rate variability, cardiovascular autonomic reflex tests, and cardiac vagal tone tests were performed based on electrocardiographic readings. Data regarding covariates (demographic-, diabetes-, and cardiovascular risk factors) were registered. Results Increased serum levels of IL-12/IL-23p40 (p < 0.01) and intercellular adhesion molecule (ICAM)-1 (p < 0.007) were associated with diminished heart rate variability measures. After all adjustments, the associations between IL-12/23p40, SDANN and VLF persisted (p = 0.001). Additionally, serum levels of vascular endothelial growth factor (VEGF)-C were associated with response to standing (p = 0.005). Discussion The few but robust associations between neurocardiac regulation and serum markers found in this study suggest systemic changes in proinflammatory, endothelial, and lymphatic function, which collectively impacts the systemic cardiovascular function. Our results warrant further exploration of IL-12/IL-23p40, ICAM-1, and VEGF-C as possible cardiovascular biomarkers in T2D that may support future decisions regarding treatment strategies for improved patient care. |
| first_indexed | 2024-12-23T11:11:43Z |
| format | Article |
| id | doaj.art-d101180051e14249b03007d6b9305f1b |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-23T11:11:43Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-d101180051e14249b03007d6b9305f1b2022-12-21T17:49:20ZengBMCCardiovascular Diabetology1475-28402022-01-0121111010.1186/s12933-021-01437-wElevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetesA. M. Wegeberg0T. Okdahl1S. Riahi2N. Ejskjaer3F. Pociot4J. Størling5B. Brock6C. Brock7Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Clinical Institute, Aalborg UniversityMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Clinical Institute, Aalborg UniversityDepartment of Cardiology, Aalborg University HospitalSteno Diabetes Center North Denmark, Aalborg University HospitalSteno Diabetes Center CopenhagenSteno Diabetes Center CopenhagenSteno Diabetes Center CopenhagenMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Clinical Institute, Aalborg UniversityAbstract Background Systemic inflammatory processes plausibly contribute to the development of cardiovascular complications, causing increased morbidity and mortality in type 2 diabetes. Circulating inflammatory markers, i.e., interleukin (IL)-6 and tumour necrosis factor-α, are associated with neurocardiac measures. We examined a broad panel of various inflammatory and inflammation-related serum markers to obtain more detailed insight into the possible neuro-immune interaction between cardiovascular regulation and systemic level of inflammation. Methods Serum samples from 100 participants with type 2 diabetes were analysed. Heart rate variability, cardiovascular autonomic reflex tests, and cardiac vagal tone tests were performed based on electrocardiographic readings. Data regarding covariates (demographic-, diabetes-, and cardiovascular risk factors) were registered. Results Increased serum levels of IL-12/IL-23p40 (p < 0.01) and intercellular adhesion molecule (ICAM)-1 (p < 0.007) were associated with diminished heart rate variability measures. After all adjustments, the associations between IL-12/23p40, SDANN and VLF persisted (p = 0.001). Additionally, serum levels of vascular endothelial growth factor (VEGF)-C were associated with response to standing (p = 0.005). Discussion The few but robust associations between neurocardiac regulation and serum markers found in this study suggest systemic changes in proinflammatory, endothelial, and lymphatic function, which collectively impacts the systemic cardiovascular function. Our results warrant further exploration of IL-12/IL-23p40, ICAM-1, and VEGF-C as possible cardiovascular biomarkers in T2D that may support future decisions regarding treatment strategies for improved patient care.https://doi.org/10.1186/s12933-021-01437-wDiabetes mellitus, type 2Cardiovascular diseasesInflammation |
| spellingShingle | A. M. Wegeberg T. Okdahl S. Riahi N. Ejskjaer F. Pociot J. Størling B. Brock C. Brock Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes Cardiovascular Diabetology Diabetes mellitus, type 2 Cardiovascular diseases Inflammation |
| title | Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes |
| title_full | Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes |
| title_fullStr | Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes |
| title_full_unstemmed | Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes |
| title_short | Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes |
| title_sort | elevated levels of interleukin 12 23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes |
| topic | Diabetes mellitus, type 2 Cardiovascular diseases Inflammation |
| url | https://doi.org/10.1186/s12933-021-01437-w |
| work_keys_str_mv | AT amwegeberg elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes AT tokdahl elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes AT sriahi elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes AT nejskjaer elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes AT fpociot elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes AT jstørling elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes AT bbrock elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes AT cbrock elevatedlevelsofinterleukin1223p40mayserveasapotentialindicatorofdysfunctionalheartratevariabilityintype2diabetes |