Diversity of Antimicrobial Peptides in Silkworm
Antimicrobial resistance is a phenomenon that the present-day world is witnessing that poses a serious threat to global health. The decline in the development of novel therapeutics over the last couple of decades has exacerbated the situation further. In this scenario, the pursuit of new alternative...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/5/1161 |
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| author | Pooja Makwana Kamidi Rahul Katsuhiko Ito Bindu Subhadra |
| author_facet | Pooja Makwana Kamidi Rahul Katsuhiko Ito Bindu Subhadra |
| author_sort | Pooja Makwana |
| collection | DOAJ |
| description | Antimicrobial resistance is a phenomenon that the present-day world is witnessing that poses a serious threat to global health. The decline in the development of novel therapeutics over the last couple of decades has exacerbated the situation further. In this scenario, the pursuit of new alternative therapeutics to commonly used antibiotics has gained predominance amongst researchers across the world. Antimicrobial peptides (AMPs) from natural sources have drawn significant interest in the recent years as promising pharmacological substitutes over the conventional antibiotics. The most notable advantage of AMPs is that microorganisms cannot develop resistance to them. Insects represent one of the potential sources of AMPs, which are synthesized as part of an innate immune defence against invading pathogens. AMPs from different insects have been extensively studied, and silkworm is one of them. Diverse classes of AMPs (including attacins, cecropins, defensins, enbocins, gloverins, lebocins and moricins) were identified from silkworm that exhibit antimicrobial property against bacteria, fungi and viruses, indicating their potential therapeutic benefits. This review briefs about the immune responses of silkworm to invading pathogens, the isolation of AMPs from silkworms, AMPs reported in silkworms and their activity against various microorganisms. |
| first_indexed | 2024-03-11T03:34:51Z |
| format | Article |
| id | doaj.art-d1012862fef347509356009b66c27910 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T03:34:51Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d1012862fef347509356009b66c279102023-11-18T02:09:32ZengMDPI AGLife2075-17292023-05-01135116110.3390/life13051161Diversity of Antimicrobial Peptides in SilkwormPooja Makwana0Kamidi Rahul1Katsuhiko Ito2Bindu Subhadra3Central Sericultural Research & Training Institute, Central Silk Board, Ministry of Textiles, Government of India, Berhampore, Murshidabad 742101, West Bengal, IndiaCentral Sericultural Research & Training Institute, Central Silk Board, Ministry of Textiles, Government of India, Berhampore, Murshidabad 742101, West Bengal, IndiaLaboratory of Sericultural Science, Department of Science of Biological Production, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi 183-8509, Tokyo, JapanDepartment of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, New York, NY 11548, USAAntimicrobial resistance is a phenomenon that the present-day world is witnessing that poses a serious threat to global health. The decline in the development of novel therapeutics over the last couple of decades has exacerbated the situation further. In this scenario, the pursuit of new alternative therapeutics to commonly used antibiotics has gained predominance amongst researchers across the world. Antimicrobial peptides (AMPs) from natural sources have drawn significant interest in the recent years as promising pharmacological substitutes over the conventional antibiotics. The most notable advantage of AMPs is that microorganisms cannot develop resistance to them. Insects represent one of the potential sources of AMPs, which are synthesized as part of an innate immune defence against invading pathogens. AMPs from different insects have been extensively studied, and silkworm is one of them. Diverse classes of AMPs (including attacins, cecropins, defensins, enbocins, gloverins, lebocins and moricins) were identified from silkworm that exhibit antimicrobial property against bacteria, fungi and viruses, indicating their potential therapeutic benefits. This review briefs about the immune responses of silkworm to invading pathogens, the isolation of AMPs from silkworms, AMPs reported in silkworms and their activity against various microorganisms.https://www.mdpi.com/2075-1729/13/5/1161antimicrobial resistancesilkworminnate immunityantimicrobial peptidesnovel therapeutics |
| spellingShingle | Pooja Makwana Kamidi Rahul Katsuhiko Ito Bindu Subhadra Diversity of Antimicrobial Peptides in Silkworm Life antimicrobial resistance silkworm innate immunity antimicrobial peptides novel therapeutics |
| title | Diversity of Antimicrobial Peptides in Silkworm |
| title_full | Diversity of Antimicrobial Peptides in Silkworm |
| title_fullStr | Diversity of Antimicrobial Peptides in Silkworm |
| title_full_unstemmed | Diversity of Antimicrobial Peptides in Silkworm |
| title_short | Diversity of Antimicrobial Peptides in Silkworm |
| title_sort | diversity of antimicrobial peptides in silkworm |
| topic | antimicrobial resistance silkworm innate immunity antimicrobial peptides novel therapeutics |
| url | https://www.mdpi.com/2075-1729/13/5/1161 |
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